人类乳腺癌中视黄酸和视黄醇的受体

Receptors for retinoic acid and retinol in human mammary carcinomas.

作者信息

Skoog L, Humla S, Klintenberg C, Pasqual M, Wallgren A

出版信息

Eur J Cancer Clin Oncol. 1985 Aug;21(8):901-6. doi: 10.1016/0277-5379(85)90105-1.

Abstract

The cellular content of receptors for retinol (CRBP) and retinoic acid (CRABP) was measured in 148 human mammary carcinomas. High levels of CRABP were found in lobular carcinomas while those of the papillary subgroup had low levels of the receptor. Intermediate values for CRABP were observed for ductal, colloid and medullar carcinomas. The cellular levels of CRBP were high in ductal carcinomas and low in papillar carcinomas. A positive correlation was observed between the receptor for estradiol and CRABP. However, no significant correlation was found between the tumor cell DNA pattern and the content of CRABP and CRBP respectively. Recurrence of disease could be predicted by the nodal status and the level of estradiol receptor while the DNA pattern and the content of receptors for retinoic acid and retinol failed.

摘要

在148例人类乳腺癌中检测了视黄醇受体（CRBP）和视黄酸受体（CRABP）的细胞含量。小叶癌中发现CRABP水平较高，而乳头状亚组的受体水平较低。导管癌、胶样癌和髓样癌的CRABP值处于中等水平。CRBP的细胞水平在导管癌中较高，在乳头状癌中较低。观察到雌二醇受体与CRABP之间呈正相关。然而，肿瘤细胞DNA模式与CRABP和CRBP的含量之间分别未发现显著相关性。疾病复发可通过淋巴结状态和雌二醇受体水平来预测，而DNA模式以及视黄酸和视黄醇受体的含量则无法做到这一点。