箭毒能够逆转由乙酰胆碱酯酶抑制剂引起的肌肉收缩功能障碍。
Curare can reverse the failure in muscle contraction caused by an AChE inhibitor.
作者信息
Bradley R J, Pagala M K, Edge M T
出版信息
Brain Res. 1986 Jul 2;377(1):194-8. doi: 10.1016/0006-8993(86)91209-6.
PMID:3015346
Abstract
Diisopropyl fluorophosphate, which is an organophosphate inhibitor of acetylcholinesterase, caused an irreversible block of neuromuscular transmission in the rat diaphragm preparation. This block could be reversed by the addition of a competitive antagonist of acetylcholine such as D-tubocurarine.
摘要
二异丙基氟磷酸酯是一种乙酰胆碱酯酶的有机磷酸酯抑制剂，它在大鼠膈肌标本中导致了神经肌肉传递的不可逆阻断。这种阻断可通过添加乙酰胆碱的竞争性拮抗剂（如筒箭毒碱）来逆转。
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