Bradley R J
Brain Res. 1986 Sep 3;381(2):397-400. doi: 10.1016/0006-8993(86)90098-3.
The organophosphate, diisopropyl fluorophosphate, and the aminoglycoside antibiotic, neomycin, both independently block neuromuscular transmission. At the neuromuscular junction, neomycin reduces the presynaptic release of acetylcholine, whereas diisopropyl fluorophosphate irreversibly inhibits acetylcholinesterase, thereby increasing the acetylcholine concentration. In the rat diaphragm preparation, the block in neuromuscular transmission caused by diisopropyl fluorophosphate could be reversed by adding neomycin.
有机磷酸酯类的二异丙基氟磷酸酯和氨基糖苷类抗生素新霉素都能独立阻断神经肌肉传递。在神经肌肉接头处，新霉素会减少乙酰胆碱的突触前释放，而二异丙基氟磷酸酯会不可逆地抑制乙酰胆碱酯酶，从而增加乙酰胆碱的浓度。在大鼠膈肌标本中，加入新霉素可逆转由二异丙基氟磷酸酯引起的神经肌肉传递阻滞。
