藤黄科藤黄属植物茎中的二苯并吡喃酮和联苯及其细胞毒性。
Xanthones and biphenyls from the stems of Garcinia cylindrocarpa and their cytotoxicity.
机构信息
Center of Excellent in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand; Natural Products and Synthesis Chemistry Research Laboratory, Department of Chemistry, Faculty of Science, Institut Teknologi Sepuluh Nopember, Kampus ITS-Sukolilo, Surabaya 60111, Indonesia.
Center of Excellent in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
出版信息
Fitoterapia. 2018 Oct;130:112-117. doi: 10.1016/j.fitote.2018.08.019. Epub 2018 Aug 25.
Six new compounds including four new xanthones, cylindroxanthones D-G (1-4), and two new biphenyls, cylindrobiphenyls A and B (5 and 6), were isolated from the stems of Garcinia cylindrocarpa together with 28 known compounds (7-34). The structures of the new compounds were established on the basis of extensive 1D and 2D NMR and HRESIMS spectroscopic analysis. Their cytotoxicity was evaluated against five human cancer cell lines including KB, HeLa S-3, MCF-7, Hep G2, and HT-29. Compound 23 showed strong cytotoxicity against KB, HeLa S-3, MCF-7, and Hep G2 cells with IC values in the range of 2.20-6.00 μM. Furthermore, compound 25 selectively exhibited good cytotoxicity against MCF-7 cells with IC value of 8.77 μM, while 31 showed good cytotoxicity against HT-29 cells with IC value of 9.18 μM.
从藤黄属植物光枝巴豆茎中分离得到 6 个化合物，包括 4 个新的紫檀烷酮，即圆柱紫檀烷酮 D-G（1-4），和 2 个新的联苯，即圆柱联苯 A 和 B（5 和 6），以及 28 个已知化合物（7-34）。新化合物的结构是基于广泛的 1D 和 2D NMR 和 HRESIMS 光谱分析确定的。对 5 种人癌细胞系（KB、Hela S-3、MCF-7、Hep G2 和 HT-29）进行了细胞毒性评价。化合物 23 对 KB、Hela S-3、MCF-7 和 Hep G2 细胞表现出较强的细胞毒性，IC 值范围为 2.20-6.00 μM。此外，化合物 25 对 MCF-7 细胞表现出良好的选择性细胞毒性，IC 值为 8.77 μM，而化合物 31 对 HT-29 细胞表现出良好的细胞毒性，IC 值为 9.18 μM。
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