Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science , Chulalongkorn University , Bangkok 10330 , Thailand.
Natural Products and Synthesis Chemistry Research Laboratory, Department of Chemistry, Faculty of Science , Institut Teknologi Sepuluh Nopember , Kampus ITS Sukolilo , Surabaya 60111 , Indonesia.
J Nat Prod. 2019 May 24;82(5):1312-1318. doi: 10.1021/acs.jnatprod.9b00046. Epub 2019 Apr 12.
Nine new xanthones, tetrandraxanthones A-I (1-9), and 22 known xanthones (10-31) were isolated from Garcinia tetrandra stem bark. The structures of 1-9 were characterized through detailed spectroscopic analysis, including HRESIMS and 2D NMR data. Among the compounds tested for their cytotoxicity, 26 showed significant cytotoxic effects against five human cancer cell lines, including MCF-7, HT-29, KB, Hep G2, and HeLa S3, with IC values in the range of 1.6-3.4 μM, while 10 and 11 were cytotoxic against the MCF-7, HeLa S3, and KB cell lines, with IC values of 4.3-9.0 μM.
从藤黄科藤黄属植物岭南山竹子茎皮中分离得到 9 个新的二氢黄酮醇类化合物，分别命名为tetrandraxanthones A-I（1-9），以及 22 个已知的二氢黄酮醇类化合物（10-31）。通过详细的光谱分析，包括高分辨质谱和二维 NMR 数据，确定了 1-9 的结构。在测试的化合物中，有 26 种对五种人癌细胞系，包括 MCF-7、HT-29、KB、Hep G2 和 HeLa S3，表现出显著的细胞毒性，IC 值范围在 1.6-3.4 μM 之间，而 10 和 11 对 MCF-7、HeLa S3 和 KB 细胞系具有细胞毒性，IC 值分别为 4.3-9.0 μM。
