中国年轻患者脉络膜新生血管的病因及特征

Etiologies and Characteristics of Choroidal Neovascularization in Young Chinese Patients.

作者信息

Liu Bing, Zhang Xiongze, Peng Yuting, Mi Lan, Wen Feng

机构信息

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou,

出版信息

Ophthalmologica. 2019;241(2):73-80. doi: 10.1159/000492133. Epub 2018 Aug 28.

DOI:10.1159/000492133

PMID:30153680

Abstract

PURPOSE

To investigate the etiologies and characteristics of choroidal neovascularization (CNV) in young Chinese patients.

METHODS

A retrospective review of young Chinese patients (< 50 years of age) with CNV from January 2010 to June 2016 was performed.

RESULTS

Of the 501 patients (537 eyes) with CNV, 58.7% were female, and 7.2% had bilateral CNV. The mean age was 35 years. The etiologies were idiopathic CNV (ICNV, 43.9%), pathologic myopia (PM, 21.9%), punctate inner choroidopathy (PIC, 17.4%), polypoidal choroidal vasculopathy (4.4%), multifocal choroiditis with panuveitis (3.6%), and other disorders (8.8%). Five hundred and six CNVs (94.2%) showed a predominantly classic CNV composition on fundus fluorescein angiography (FFA) and 316 CNVs (96.6%) were type 2 CNV on optical coherence tomography (OCT).

CONCLUSION

The etiologies of CNV in young Chinese patients were diverse, and ICNV, PM, and PIC were the three most common etiologies. Most CNVs were classic on FFA and type 2 on OCT.

摘要

目的

探讨中国年轻患者脉络膜新生血管（CNV）的病因及特征。

方法

对2010年1月至2016年6月的中国年轻（<50岁）CNV患者进行回顾性研究。

结果

501例（537只眼）CNV患者中，58.7%为女性，7.2%为双侧CNV。平均年龄为35岁。病因包括特发性CNV（ICNV，43.9%）、病理性近视（PM，21.9%）、点状内层脉络膜病变（PIC，17.4%）、息肉样脉络膜血管病变（4.4%）、多灶性脉络膜炎伴全葡萄膜炎（3.6%）和其他疾病（8.8%）。506只CNV（94.2%）在眼底荧光血管造影（FFA）上主要表现为典型CNV成分，316只CNV（96.6%）在光学相干断层扫描（OCT）上为2型CNV。