Ophtalmopôle, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France.
Ophthalmology Department, Republic Medical Center, Le Mans, France.
Ocul Immunol Inflamm. 2024 Jul;32(5):602-608. doi: 10.1080/09273948.2023.2181189. Epub 2023 Mar 3.
To assess the effect of corticosteroids (CS) on choroidal neovascularization (CNV) occurrence and recurrence of activity over 2 years in patients with punctate inner choroidopathy (PIC) or multifocal choroiditis (MFC).
Retrospective longitudinal study. Previous use of CS was analyzed between group without CNV and group with CNV occurrence and recurrence.
Thirty-six patients were included. Patients with CNV were less likely to have received CS in the 6 months following PIC or MFC diagnosis (17% versus 65%, p-value = 0.01). Patients with CNV who had a recurrence of neovascular activity were less likely to have received a previous CS therapy (20% versus 78%; odds ratio = 0.08, p-value = 0.005).
This study suggests that patients with PIC and MFC should be treated by CS to prevent CNV development and decrease CNV recurrences.
评估皮质类固醇（CS）对 2 年内点状内层脉络膜炎（PIC）或多发性脉络膜炎（MFC）患者脉络膜新生血管（CNV）发生和活动复发的影响。
回顾性纵向研究。分析无 CNV 组和 CNV 发生及复发组 CS 的既往使用情况。
共纳入 36 例患者。与 PIC 或 MFC 诊断后 6 个月内未接受 CS 治疗的患者相比，CNV 患者更不可能接受 CS 治疗（17%比 65%，p 值=0.01）。发生新生血管活动复发的 CNV 患者，更不可能接受过 CS 治疗（20%比 78%；比值比=0.08，p 值=0.005）。
本研究表明，应通过 CS 治疗 PIC 和 MFC 患者，以预防 CNV 发生并减少 CNV 复发。
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