[慢性肝炎、肝硬化、原发性肝癌与乙肝病毒感染。在萨赫勒地区一家医院环境中的流行病学研究。关于185例病例]

[Chronic hepatitis, liver cirrhosis, primary liver cancer and virus HB infection. Epidemiologic study in a sahelian hospital milieu. Apropos of 185 cases].

作者信息

Cénac A, Develoux M, Lamothe F, Soubiran G, Vetter J M, Trepo C

出版信息

Bull Soc Pathol Exot Filiales. 1985;78(5 Pt 2):896-902.

Abstract

From December 1982 to June 1985, 185 patients with signs of chronic liver disease are investigated in National Hospital (Niamey, Republic of Niger). A first group ("Hepatopathy") of 131 patients (75 males, 56 females) is made of 3 chronic liver diseases: 35 chronic hepatitis (CH), 58 hepatic cirrhosis (HC), 38 hepatocellular carcinoma (HCC). A second group ("Controls") of 54 patients (29 males, 25 females) is made of miscellaneous diseases other than CH, HC, HCC. In the first group ("Hepatopathy") serum hepatitis B virus (HBV) surface antigen (HBsAg-radioimmunoassay) is present in 64.9% (85/131). In the second group ("Controls") serum HBsAg is present in 3.7% (2/54) (Chi-2 test P less than 10(-9)). Serum HBsAg prevalence is more than 50% in each group of CH, HC and HCC. A maximum value is observed in males with HCC (75.7%). These results demonstrate the importance of evolutive HBV infection in the course of CH, HC and HCC in the sahelian region.

摘要

1982年12月至1985年6月，尼亚美国立医院（尼日尔共和国）对185例有慢性肝病体征的患者进行了调查。第一组（“肝病组”）131例患者（男75例，女56例）由3种慢性肝病组成：35例慢性肝炎（CH）、58例肝硬化（HC）、38例肝细胞癌（HCC）。第二组（“对照组”）54例患者（男29例，女25例）由CH、HC、HCC以外的其他杂病组成。在第一组（“肝病组”）中，血清乙型肝炎病毒（HBV）表面抗原（HBsAg-放射免疫测定）阳性率为64.9%（85/131）。在第二组（“对照组”）中，血清HBsAg阳性率为3.7%（2/54）（卡方检验P<10⁻⁹）。CH、HC和HCC每组的血清HBsAg患病率均超过50%。在男性HCC患者中观察到最高值（75.7%）。这些结果表明，在萨赫勒地区，演变中的HBV感染在CH、HC和HCC病程中具有重要意义。