Rinaldo C R, Kingsley L A, Lyter D W, Rabin B S, Atchison R W, Bodner A J, Weiss S H, Saxinger W C
J Infect Dis. 1986 Oct;154(4):556-61. doi: 10.1093/infdis/154.4.556.
Homosexual men were studied for associations among human T-lymphotropic virus type III (HTLV-III) infection, Epstein-Barr virus (EBV) infection, and T cell abnormalities. The presence of IgG antibody to EBV capsid antigen and antibody to EBV early antigen was significantly associated with augmented counts of suppressor T cells in healthy HTLV-III-seronegative men. HTLV-III-seropositive asymptomatic subjects had significantly enhanced titers of antibody to EBV and lower ratios of helper to suppressor T cells compared with HTLV-III-seronegative homosexual men. Of three men who seroconverted to HTLV-III, two had a greater than fourfold increase in titer of IgG antibody to EBV capsid antigen after seroconversion. These results suggest that the interaction of HTLV-III and EBV and their immunologic perturbations are significant in the natural history of this retrovirus infection in homosexual men.
对同性恋男性进行了研究，以探讨人类嗜T淋巴细胞病毒III型（HTLV-III）感染、爱泼斯坦-巴尔病毒（EBV）感染与T细胞异常之间的关联。在健康的HTLV-III血清阴性男性中，EBV衣壳抗原IgG抗体和EBV早期抗原抗体的存在与抑制性T细胞计数增加显著相关。与HTLV-III血清阴性的同性恋男性相比，HTLV-III血清阳性的无症状受试者的EBV抗体滴度显著升高，辅助性T细胞与抑制性T细胞的比例较低。在血清转化为HTLV-III的三名男性中，有两名在血清转化后IgG抗EBV衣壳抗原抗体滴度增加了四倍以上。这些结果表明，HTLV-III和EBV的相互作用及其免疫扰动在同性恋男性这种逆转录病毒感染的自然史中具有重要意义。
