King Benjamin A, Rosenberger Elizabeth U, Morales-Tirado Vanessa M, Wilson Matthew W
Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, College of Medicine, Memphis, TN, USA,
Department of Surgery, St Jude Children's Research Hospital, Memphis, TN, USA,
Clin Ophthalmol. 2018 Aug 17;12:1459-1463. doi: 10.2147/OPTH.S172464. eCollection 2018.
To report the clinical features of uveal metastases in a geographic region associated with high tobacco use.
Medical records from all patients diagnosed with uveal metastasis at a single tertiary referral center between 2000 and 2017 were retrospectively reviewed. The clinical features and the primary tumor site associated with each metastatic lesion were recorded.
Ninety-nine uveal metastatic tumors were identified in 85 eyes of 74 patients (34 males). Median age at diagnosis was 62 years. Median tumor diameter was 11.6 mm and median height was 3.1 mm. Carcinoma of the lung was the most common primary tumor occurring in 37 patients (50%) followed by breast in 16 patients (21%). Among females, metastatic lesions originated from the lung in 18 patients and from the breast in 16 patients. Median survival following intraocular metastasis was 9 months for patients with a primary lung malignancy and 36 months for patients with breast cancer (log-rank test, =0.002).
Intraocular metastasis is more frequently observed in patients with carcinomas of the lung rather than breast at our treatment center. Both regional and global changes in cancer epidemiology most likely account for the findings in this study.
报告在一个烟草使用率高的地理区域葡萄膜转移瘤的临床特征。
回顾性分析2000年至2017年期间在一家三级转诊中心诊断为葡萄膜转移瘤的所有患者的病历。记录每个转移瘤的临床特征和相关的原发肿瘤部位。
在74例患者（34例男性）的85只眼中发现了99个葡萄膜转移瘤。诊断时的中位年龄为62岁。肿瘤中位直径为11.6mm，中位高度为3.1mm。肺癌是最常见的原发肿瘤，发生在37例患者（50%）中，其次是乳腺癌，发生在16例患者（21%）中。在女性患者中，18例转移瘤起源于肺，16例起源于乳腺。眼内转移后，原发性肺癌患者的中位生存期为9个月，乳腺癌患者为36个月（对数秩检验，P=0.002）。
在我们的治疗中心，眼内转移在肺癌患者中比乳腺癌患者中更常见。癌症流行病学的区域和全球变化很可能是本研究结果的原因。
