Jie Fan, Yin Guanghao, Yang Wei, Yang Modi, Gao Shuohui, Lv Jiayin, Li Bingjin
Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, China.
Department of Gastrointestinal Colorectal Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
Front Neurosci. 2018 Aug 14;12:562. doi: 10.3389/fnins.2018.00562. eCollection 2018.
The amygdala is an almond-shaped nucleus located deep and medially within the temporal lobe and is thought to play a crucial role in the regulation of emotional processes. GABAergic neurotransmission inhibits the amygdala and prevents us from generating inappropriate emotional and behavioral responses. Stress may cause the reduction of the GABAergic interneuronal network and the development of neuropsychological diseases. In this review, we summarize the recent evidence investigating the possible mechanisms underlying GABAergic control of the amygdala and its interaction with acute and chronic stress. Taken together, this study may contribute to future progress in finding new approaches to reverse the attenuation of GABAergic neurotransmission induced by stress in the amygdala.
杏仁核是位于颞叶深处内侧的杏仁状核团，被认为在情绪过程的调节中起关键作用。γ-氨基丁酸（GABA）能神经传递抑制杏仁核，防止我们产生不适当的情绪和行为反应。压力可能导致GABA能中间神经元网络减少及神经心理疾病的发生。在本综述中，我们总结了近期有关研究GABA能控制杏仁核的潜在机制及其与急慢性应激相互作用的证据。综上所述，本研究可能有助于未来在寻找新方法以逆转应激诱导的杏仁核GABA能神经传递减弱方面取得进展。
