Natthee Pattamaporn, Wattanathorn Jintanaporn, Thukham-Mee Wipawee, Paholpak Pongsatorn, Rangseekajee Poonsri, Piyavhatkul Nawanant, Wattanathorn Suphayanakorn, Muchimapura Supaporn, Tong-Un Terdthai
Department of Physiology and Graduate School (Neuroscience Program), Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Foods. 2024 Dec 1;13(23):3884. doi: 10.3390/foods13233884.
We hypothesized that consumption of a diet containing the functional ingredient from black sticky rice, which is rich in anthocyanin, over a five-day period would improve anxiety, depression, and stress perception in adult volunteers based on the benefits of this compound. In this study, a total of 46 male and female adult volunteers with mild and moderate stress level were assigned to groups consuming a breakfast meal containing an anthocyanin-enriched functional ingredient at doses of 2 and 4 g per day for 5 days. The volunteers consumed three meals with a low DII but high DAQ-S, and the total calories consumed during the study period was 2000 kcal/day. Mental well-being, including depression, anxiety, and stress, together with AChE, MAO, Nrf2, 8OHdG, MDA, and the density of and spp., were assessed at baseline and at the end of the study. Safety parameters were also examined. A diet containing both doses of the anthocyanin-enriched functional ingredient with a low DII but high DAQ-S was found to improve anxiety, depression, and stress, with changes in 8-OHdG and IL-6 levels. No other changes and toxicity-related parameters were observed. Our results show that the novel functional ingredient can improve anxiety, depression, and stress perception partly by decreasing oxidative stress and inflammation; however, randomized, double-blind, placebo-controlled studies with a larger sample size should be performed to confirm this benefit.
我们假设，基于这种化合物的益处，连续五天食用含有富含花青素的黑糯米功能成分的饮食，将改善成年志愿者的焦虑、抑郁和压力感知。在本研究中，共有46名轻度和中度压力水平的成年男女志愿者被分配到每天食用含有2克和4克花青素富集功能成分早餐的组中，持续5天。志愿者食用低膳食炎症指数（DII）但高饮食抗氧化质量（DAQ-S）的三餐，研究期间消耗的总热量为2000千卡/天。在基线和研究结束时评估包括抑郁、焦虑和压力在内的心理健康，以及乙酰胆碱酯酶（AChE）、单胺氧化酶（MAO）、核因子E2相关因子2（Nrf2）、8-羟基脱氧鸟苷（8OHdG）、丙二醛（MDA）以及肠道菌群密度等指标。还检查了安全参数。发现含有两种剂量花青素富集功能成分且低DII但高DAQ-S的饮食可改善焦虑、抑郁和压力，并伴有8-OHdG和白细胞介素-6（IL-6）水平的变化。未观察到其他变化和与毒性相关的参数。我们的结果表明，这种新型功能成分可部分通过降低氧化应激和炎症来改善焦虑、抑郁和压力感知；然而，应进行更大样本量的随机、双盲、安慰剂对照研究以证实这一益处。
