Gheisari Mehdi, Ahmadzadeh Arman, Nobari Nilofar, Iranmanesh Behzad, Mozafari Nikoo
Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Rheumatology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Dermatol Res Pract. 2018 Aug 1;2018:6568016. doi: 10.1155/2018/6568016. eCollection 2018.
Systemic sclerosis (SSc) is a rare systemic autoimmune disease, characterized by progressive cutaneous and internal organ fibrosis. Orofacial manifestations of systemic sclerosis are extremely disabling and treatment options are limited. In this study, we aimed to assess the safety and efficacy of autologous fat grafting in the face of patients with systemic sclerosis. We enrolled 16 SSc patients suffering from facial sclerosis and limited mouth opening capacity. Autologous fat injection ranging from 15 to 40 ml was administered per patient, based on their face morphology. The patients were evaluated at baseline and 3 months after fat injection. Evaluations included mouth opening capacity, mouth handicap in systemic sclerosis (MHISS), Rodnan skin sclerosis score, skin biophysical properties using a sensitive biometrologic device with the assessment of cutaneous resonance running time (CRRT), volumizing and aesthetic effects based on pre- and posttreatment photographs, possible side effects, and global patient satisfaction. Clinical assessment showed autologous fat transfer significantly improved mouth opening capacity and the MHISS and Rodnan score of patients with facial scleroderma (p value <.001). The aesthetic and/or functional results of fat injection were satisfying to about 80% of the patients. The changes in CRRT values were not significant. Our findings support the possible therapeutic role of autologous fat grafting in improving facial scleroderma both in aesthetic and in functional aspects. This trial is registered with IRCT20180209038677N1.
系统性硬化症（SSc）是一种罕见的全身性自身免疫性疾病，其特征为进行性皮肤和内脏器官纤维化。系统性硬化症的口面部表现极具致残性，且治疗选择有限。在本研究中，我们旨在评估自体脂肪移植对系统性硬化症患者面部的安全性和有效性。我们招募了16名患有面部硬化症且张口能力受限的系统性硬化症患者。根据患者面部形态，每位患者接受15至40毫升的自体脂肪注射。在基线期和脂肪注射后3个月对患者进行评估。评估内容包括张口能力、系统性硬化症口部功能障碍（MHISS）、罗德南皮肤硬化评分、使用敏感生物计量设备评估皮肤生物物理特性并测定皮肤共振运行时间（CRRT）、根据治疗前后照片评估容积增加和美学效果、可能的副作用以及患者总体满意度。临床评估显示，自体脂肪移植显著改善了面部硬皮病患者的张口能力、MHISS和罗德南评分（p值<.001）。约80%的患者对脂肪注射的美学和/或功能效果感到满意。CRRT值的变化不显著。我们的研究结果支持自体脂肪移植在改善面部硬皮病的美学和功能方面可能具有治疗作用。本试验已在IRCT20180209038677N1注册。
