Abellan Lopez M, Philandrianos C, Daumas A, Velier M, Arcani R, Jouve E, Jaloux C, Bertrand B, Magalon J, Dignat-George F, Granel B, Casanova D, Sabatier F
Plastic Surgery Department, La Conception Hospital, AP-HM, 13005 Marseille, France; Aix Marseille University, INSERM, INRA, C2VN, 13005 Marseille, France.
Plastic Surgery Department, La Conception Hospital, AP-HM, 13005 Marseille, France.
Ann Chir Plast Esthet. 2023 Apr;68(2):152-161. doi: 10.1016/j.anplas.2022.07.016. Epub 2022 Aug 18.
Combining fat graft with platelet derived products is now common practice in regenerative surgery. We proposed to assess the safety and efficacy of Platelet-Rich Plasma (PRP) addition to a micro-lipofilling protocol for facial treatment of patients suffering from Systemic Sclerosis (SSc).
Main objective was to evaluate the improvement of the Mouth Handicap In Systemic Sclerosis (MHISS) scale score at 6 months post-therapy.
Included SSc patients had a MHISS score equal or up to 20. Surgery was performed under general anesthesia. Micro-fat and PRP (CCA-NA from DEPA Classification) were mixed in a 70/30 ratio, before injection in peri-oral sites according to a specific protocol. Efficacy criteria were recorded at baseline, 3 and 6 months. Moreover, we compared this cohort (current study) to a former (2015) non-enriched micro-lipofilling cohort in the same indication, using the same protocol.
Thirteen women patients with mean age of 53.2 years (±14.3) have been included. At baseline, mean MHISS score was 29.5 (±8.7) and significantly decreased to 22.5 (±7.8) at 6 months (P=0.016), corresponding to a 22.0% of improvement from baseline, with a mean decrease of 6.5 points (±7.5) at 6 months. Patients received a mean volume of 30.8ml PRP-micro-fat (±8.1ml).
PRP addition appeared beneficial, however, controlled studies are required to determine its superiority to facial micro-lipofilling.
脂肪移植与血小板衍生产品相结合目前是再生外科的常见做法。我们建议评估在系统性硬化症（SSc）患者面部治疗的微脂肪填充方案中添加富血小板血浆（PRP）的安全性和有效性。
主要目的是评估治疗后6个月时系统性硬化症口腔功能障碍量表（MHISS）评分的改善情况。
纳入的SSc患者MHISS评分等于或高达20分。手术在全身麻醉下进行。根据特定方案，将微脂肪和PRP（DEPA分类中的CCA-NA）按70/30的比例混合，然后注射到口周部位。在基线、3个月和6个月时记录疗效标准。此外，我们使用相同的方案，将该队列（当前研究）与同一适应症的前一个（2015年）未富集微脂肪填充队列进行比较。
纳入了13名平均年龄为53.2岁（±14.3）的女性患者。基线时，平均MHISS评分为29.5（±8.7），6个月时显著降至22.5（±7.8）（P=0.016），相当于较基线改善了22.0%，6个月时平均下降6.5分（±7.5）。患者接受的PRP-微脂肪平均体积为30.8ml（±8.1ml）。
添加PRP似乎有益，然而，需要进行对照研究以确定其相对于面部微脂肪填充的优越性。
