Lei Jian-Hua, Gong Xing, Xiao Xin-Qiang, Chen Zi, Peng Feng
Department of Infectious Diseases, Second Xiangya Hospital, Central South University, Changsha, China.
Arch Med Sci. 2018 Aug;14(5):1055-1060. doi: 10.5114/aoms.2017.70664. Epub 2017 Oct 12.
Few large-scale investigations on genotype (GT) distribution of hepatitis C virus (HCV) in Hunan Province, China, are reported.
We recruited all of the 952 patients in the census register of Hunan Province who were first diagnosed with HCV infection in the Second Xiangya Hospital, Central South University in 2014-2016. HCV genotypes were surveyed. The genotype distribution pattern was compared with those of the neighboring regions in China.
Among the 952 patients, genotype 1 (GT1) (69.9%) was the most common HCV genotype, followed by GT6 (19.0%), GT3 (8.4%), and GT2 (2.6%). GT4 and GT5 were not found. One case had mixed infection of GT3 and GT6. Predominance of GT1 HCV was more evident in the patients aged ≥ 40 years than in those aged < 40 years (79.5% vs. 47.9%, χ = 95.993, < 0.001). HCV genotype distribution had gender difference (χ = 44.695, < 0.001), with GT3 and GT6 more prevalent in males than in females (36.2% vs. 18.2%, χ = 39.088, < 0.001) while GT1 more prevalent in females than in males (80.1% vs. 60.3%, χ = 44.276, < 0.001). Though Hunan Province is located in central China, its HCV genotype priority was similar with the change trend in south and southwest China, while distinguished from those of other regions, in particular from the neighboring central province, Hubei Province.
HCV GT1 was the most predominant HCV genotype in Hunan Province, and GT6 and GT3 accounted for a significant percentage, especially in young patients. The HCV distribution pattern was more similar to those of the regions in south China.
中国湖南省关于丙型肝炎病毒（HCV）基因型（GT）分布的大规模调查报道较少。
我们纳入了2014 - 2016年在中南大学湘雅二医院首次诊断为HCV感染的湖南省户籍登记中的所有952例患者。对HCV基因型进行了检测。将基因型分布模式与中国邻近地区的模式进行了比较。
在952例患者中，基因型1（GT1）（69.9%）是最常见的HCV基因型，其次是GT6（19.0%）、GT3（8.4%）和GT2（2.6%）。未发现GT4和GT5。1例患者为GT3和GT6混合感染。GT1 HCV在年龄≥40岁的患者中比<40岁的患者中更为明显（79.5%对47.9%，χ = 95.993，<0.001）。HCV基因型分布存在性别差异（χ = 44.695，<0.001），GT3和GT6在男性中比在女性中更普遍（36.2%对18.2%，χ = 39.088，<0.001），而GT1在女性中比在男性中更普遍（80.1%对60.3%，χ = 44.276，<0.001）。尽管湖南省位于中国中部，但其HCV基因型优势与中国南部和西南部的变化趋势相似，而与其他地区不同，特别是与邻近的中部省份湖北省不同。
HCV GT1是湖南省最主要的HCV基因型，GT6和GT3占相当比例，尤其是在年轻患者中。HCV分布模式与中国南部地区更相似。
