Ji Yuying, Li Miaoling, Zhang Xiongze, Peng Yuting, Wen Feng
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 South Xianlie Road, Guangzhou 510060, China.
J Ophthalmol. 2018 Aug 1;2018:9450297. doi: 10.1155/2018/9450297. eCollection 2018.
Whether sleep disturbance is related with central serous chorioretinopathy (CSC) is still in controversy. This study is designed to investigate sleep status in CSC using definite and well-established methods.
A total of 134 CSC patients and 134 age- and sex-matched normal controls were recruited in the study. Demographic data were collected through a questionnaire. Body mass index (BMI) was calculated by weight divided by height squared. The Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) were administered to all subjects to assess the sleep quality and daytime sleepiness, respectively. Depression Anxiety Stress Scales 21-item version (DASS-21) was also used to evaluate the emotion status as a positive control. Poor sleep quality was defined as PSQI > 5 and sleep apnea tendency as ESS > 10. Positive criteria scores were ≥10 for depression, ≥8 for anxiety, and ≥15 for stress.
There was no significant difference of BMI between the two groups (=0.075). The prevalence of poor sleep quality (58.2% versus 23.9%; < 0.001) in CSC patients was significantly higher than normal. Specifically, CSC patients presented worse performance in certain components of sleep quality, that is, sleep latency, sleep duration, and sleep efficiency. More participants had stress (23.9% versus 3%, < 0.001), depression (25.4% versus 10.4%; =0.001), and anxiety (28.4% versus 14.9%; =0.008) emotions in CSC than that in normal. No significant difference was observed in sleep apnea tendency. Through logistic regression analysis, CSC patients were more likely to be in poor sleep quality ( < 0.001; OR 3.608 (2.071-6.285)) and stress emotion (=0.002, OR 6.734 (1.997-22.711)).
Poor sleep quality is risk factor for CSC patients. Attention of sleep quality should be paid when treating them.
睡眠障碍是否与中心性浆液性脉络膜视网膜病变（CSC）相关仍存在争议。本研究旨在采用明确且成熟的方法调查CSC患者的睡眠状况。
本研究共纳入134例CSC患者和134例年龄及性别匹配的正常对照。通过问卷调查收集人口统计学数据。体重指数（BMI）通过体重除以身高的平方计算得出。对所有受试者进行匹兹堡睡眠质量指数（PSQI）和爱泼华嗜睡量表（ESS）评估，分别用于评估睡眠质量和日间嗜睡程度。还使用抑郁焦虑压力量表21项版本（DASS - 21）评估情绪状态作为阳性对照。睡眠质量差定义为PSQI＞5，睡眠呼吸暂停倾向定义为ESS＞10。抑郁阳性标准分数≥10，焦虑≥8，压力≥15。
两组间BMI无显著差异（P = 0.075）。CSC患者睡眠质量差的患病率（58.2%对23.9%；P＜0.001）显著高于正常对照组。具体而言，CSC患者在睡眠质量的某些方面表现更差，即入睡潜伏期、睡眠时间和睡眠效率。与正常对照组相比，更多CSC患者存在压力情绪（23.9%对3%，P＜0.001）、抑郁情绪（25.4%对10.4%；P = 0.001）和焦虑情绪（28.4%对14.9%；P = 0.008）。睡眠呼吸暂停倾向方面未观察到显著差异。通过逻辑回归分析，CSC患者更易出现睡眠质量差（P＜0.001；OR 3.608（2.071 - 6.285））和压力情绪（P = 0.002，OR 6.734（1.997 - 22.711））。
睡眠质量差是CSC患者的危险因素。治疗CSC患者时应关注其睡眠质量。
