Ekun Oloruntoba Ayodele, Olawumi Oluwatumininu Mary, Makwe Christian Chigozie, Ogidi Nkeiruka Ogochukwu
Department of Medical Laboratory Science, College of Medicine, University of Lagos, Nigeria.
Department of Obstetrics and Gynaecology, College of Medicine, University of Lagos, Nigeria.
Int J Reprod Med. 2018 Jul 31;2018:1594182. doi: 10.1155/2018/1594182. eCollection 2018.
Preeclampsia is a pregnancy specific syndrome. Studies have shown that preeclampsia has multiorgan dysfunction effects. This study evaluated biomarkers of renal and liver function among preeclamptic Nigerian women.
This was a cross-sectional study conducted among 49 preeclamptic women and 50 normotensive healthy pregnant women.
The baseline data comprising age, gestational age, and blood pressure were obtained. Venous blood and spot urine samples were collected from each participant. Plasma obtained from blood samples taken into lithium heparinized vacutainer bottles was assayed for electrolytes, urea, creatinine, total protein, albumin, and uric acid, while sera samples from blood samples taken into serum separation tube- (SST-) gel vacutainer were assayed for aspartate transaminase and alanine transaminase using ion selective electrode technique and Cobas autoanalyzer. Spot urine samples were assayed for protein and creatinine using Pyrogallol's reagent and Jaffe's methods, respectively. Microalbuminuria (protein/creatinine ratio) was generated from spot urine protein and creatinine data.
The plasma sodium, total protein, and albumin in preeclamptic group were significantly decreased (p<0.05) when compared with control. There was statistically significant increase (p<0.05) in microalbuminuria, plasma potassium, urea, creatinine, uric acid levels, serum AST, and ALT activities in preeclamptic group. A positive association (p<0.05) between alanine aminotransferase and biomarkers of renal function was observed.
Preeclampsia has deleterious effects on renal and liver function as shown by alteration of these parameters.
子痫前期是一种妊娠特有的综合征。研究表明，子痫前期具有多器官功能障碍效应。本研究评估了尼日利亚子痫前期女性的肾功能和肝功能生物标志物。
这是一项横断面研究，对49例子痫前期女性和50例血压正常的健康孕妇进行了研究。
获取包括年龄、孕周和血压在内的基线数据。从每位参与者采集静脉血和随机尿样。将采集到锂肝素化真空管中的血样所得血浆用于检测电解质、尿素、肌酐、总蛋白、白蛋白和尿酸，而采集到血清分离管（SST）凝胶真空管中的血样所得血清样本则使用离子选择电极技术和Cobas自动分析仪检测天冬氨酸转氨酶和丙氨酸转氨酶。随机尿样分别使用连苯三酚试剂和杰氏法检测蛋白质和肌酐。根据随机尿蛋白和肌酐数据得出微量白蛋白尿（蛋白/肌酐比值）。
与对照组相比，子痫前期组的血浆钠、总蛋白和白蛋白显著降低（p<0.05）。子痫前期组的微量白蛋白尿、血浆钾、尿素、肌酐、尿酸水平、血清AST和ALT活性有统计学显著升高（p<0.05）。观察到丙氨酸转氨酶与肾功能生物标志物之间存在正相关（p<0.05）。
如这些参数的改变所示，子痫前期对肾功能和肝功能有有害影响。
