Ernest Mario School of Pharmacy, 160 Frelinghuysen Rd., Piscataway, NJ, 08854, USA.
Massachusetts College of Pharmacy and Health Sciences, 13516 Bonnie Dale Drive, Gaithersburg, MD, 20878, USA.
Rheumatol Int. 2018 Dec;38(12):2209-2216. doi: 10.1007/s00296-018-4119-9. Epub 2018 Aug 22.
Raynaud's phenomenon (RP) is a microvascular condition in which reversible ischemic attacks occur in the extremities. Due to the unpredictable nature of these attacks, pharmacologic agents that can be administered on as-needed basis are currently being sought after. Topical nitrates are well suited for as-needed use, and several different formulations have been studied for the treatment of RP, including ointments, gels, patches, and tapes. However, these different dosage forms are not all equal in terms of safety and efficacy, and not every one is commercially available for use in clinical practice. Nitroglycerin ointment is commercially available, and it has less systemic side effects than other topical formulations. Since its role in the treatment of RP has not yet been completely established, we performed a systematic search of Medline, Embase, and the Cochrane Central Register of Controlled Trials to evaluate its safety and efficacy. A total of 1125 studies were identified, and 7 were included in our review. Although the included studies used different measures of efficacy, the majority reported positive responses to nitroglycerin ointment. The benefit of nitroglycerin ointment in the treatment of RP may be further realized through more robust investigation.
雷诺现象（RP）是一种微血管疾病，其特征是四肢发生可逆性缺血性发作。由于这些发作具有不可预测的性质，因此目前正在寻找可按需给予的药物治疗。局部硝酸酯类药物非常适合按需使用，并且已经研究了几种不同的制剂来治疗 RP，包括软膏、凝胶、贴剂和胶带。然而，这些不同的剂型在安全性和疗效方面并非完全相同，并非所有剂型都可在临床实践中商业使用。硝酸甘油软膏可商业购买，其全身性副作用小于其他局部制剂。由于其在 RP 治疗中的作用尚未完全确定，我们对 Medline、Embase 和 Cochrane 对照试验中心注册库进行了系统检索，以评估其安全性和疗效。共确定了 1125 项研究，其中 7 项研究纳入了我们的综述。尽管纳入的研究使用了不同的疗效衡量标准，但大多数研究报告了硝酸甘油软膏的积极反应。通过更有力的研究，可能会进一步认识到硝酸甘油软膏在 RP 治疗中的益处。
