Brillon D, Nabil N, Jacobs L S
Endocr Res. 1986;12(2):137-46. doi: 10.1080/07435808609035433.
In order to clarify the roles of cholinergic and serotonergic neurotransmission in the mediation of exercise-induced growth hormone (GH) release, normal young volunteers of both sexes were studied. Exercise was for 20 minutes at 800 kpm for the men and 500 kpm for the women. Pretreatment with 0.4 mg atropine 1 hour prior to exercise, or with methysergide 2 mg po q 6 h for 48 hours prior to exercise, were used to evaluate the influence of cholinergic and serotonergic blockade, respectively. Five of the ten men studied failed to raise GH values with exercise, perhaps because the exercise was not vigorous enough for their high degree of fitness. Of three non-responders restudied, at the same workload, one responded on the second occasion. The mean peak GH with exercise 13.4 +/- 3.27 ng/ml, was reduced to 2.4 +/- 1.28 ng/ml (p less than 0.01) after atropine, but was unaffected by methysergide (15.2 +/- 6.58 ng/ml, p greater than 0.5). Prolactin did not rise with exercise, and was not affected by atropine, but lowered by methysergide as expected. Cholinergic neurotransmission therefore represents a key link in exercise-induced GH secretion, but serotonergic influences are probably not involved.
为了阐明胆碱能和5-羟色胺能神经传递在运动诱导的生长激素（GH）释放介导中的作用，对正常的青年男女志愿者进行了研究。男性以800千磅米的强度运动20分钟，女性以500千磅米的强度运动。分别在运动前1小时用0.4毫克阿托品预处理，或在运动前48小时口服2毫克麦角新碱，每6小时一次，以评估胆碱能和5-羟色胺能阻断的影响。所研究的10名男性中有5名运动时未能提高GH值，可能是因为运动强度对他们的高身体素质来说不够大。在相同工作量下对3名无反应者进行再次研究，其中1名在第二次测试时有反应。运动时GH的平均峰值为13.4±3.27纳克/毫升，阿托品处理后降至2.4±1.28纳克/毫升（p<0.01），但麦角新碱对其无影响（15.2±6.58纳克/毫升，p>0.5）。催乳素在运动时未升高，且不受阿托品影响，但如预期的那样被麦角新碱降低。因此，胆碱能神经传递是运动诱导的GH分泌的关键环节，但可能不涉及5-羟色胺能的影响。
