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利用光学相干层析成像技术和有限时域差分法对多重散射效应的散射系数进行定量分析。

Quantifying scattering coefficient for multiple scattering effect by combining optical coherence tomography with finite-difference time-domain simulation method.

机构信息

National Taiwan University, Graduate Institute of Photonics and Optoelectronics, Department of Elect, Taiwan.

National Taiwan University, Graduate Institute of Electronics Engineering, Department of Electrical, Taiwan.

出版信息

J Biomed Opt. 2018 Aug;23(8):1-9. doi: 10.1117/1.JBO.23.8.086004.

DOI:10.1117/1.JBO.23.8.086004
PMID:30156065
Abstract

In optical coherence tomography (OCT) systems, to precisely obtain the scattering properties of samples is an essential issue in diagnostic applications. Especially with a higher density turbid medium, the light interferes among the adjacent scatters. Combining an OCT experiment with the finite-difference time-domain simulation method, the multiple scattering effect is shown to affect the scattering properties of medium depending on the interparticle spacing. The far-field scattering phase function of scatters with various diameters was simulated to further analyze the corresponding anisotropy factors, which can be introduced into the extended Huygens-Fresnel theory to find the scattering coefficient of measured samples.

摘要

在光学相干断层扫描(OCT)系统中,精确获取样品的散射特性是诊断应用中的一个重要问题。特别是在更高密度的混浊介质中,光会在相邻散射体之间相互干扰。通过将 OCT 实验与有限差分时域模拟方法相结合,可以发现多散射效应对介质的散射特性的影响取决于粒子间的间距。模拟了不同直径的散射体的远场散射相位函数,以进一步分析相应的各向异性因子,这些因子可以被引入扩展的惠更斯-菲涅尔理论,以找到测量样品的散射系数。

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