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碳纳米材料在癌症靶向治疗药物中的应用:批判性综述。

Carbon Nanomaterials for Targeted Cancer Therapy Drugs: A Critical Review.

机构信息

Department of Human Pharmacology and Toxicology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho 1946/1, 612 42, Brno, Czech Republic.

Department of Biomedical and Environmental Analyses, Faculty of Pharmacy with Division of Laboratory Medicine, Wroclaw Medical University, Borowska 211, 50-556, Wroclaw, Poland.

出版信息

Chem Rec. 2019 Feb;19(2-3):502-522. doi: 10.1002/tcr.201800038. Epub 2018 Aug 29.

Abstract

Cancer represents one of the main causes of human death in developed countries. Most current therapies, unfortunately, carry a number of side effects, such as toxicity and damage to healthy cells, as well as the risk of resistance and recurrence. Therefore, cancer research is trying to develop therapeutic procedures with minimal negative consequences. The use of nanomaterial-based systems appears to be one of them. In recent years, great progress has been made in the field using nanomaterials with high potential in biomedical applications. Carbon nanomaterials, thanks to their unique physicochemical properties, are gaining more and more popularity in cancer therapy. They are valued especially for their ability to deliver drugs or small therapeutic molecules to these cells. Through surface functionalization, they can specifically target tumor tissues, increasing the therapeutic potential and significantly reducing the adverse effects of therapy. Their potential future use could, therefore, be as vehicles for drug delivery. This review presents the latest findings of research studies using carbon nanomaterials in the treatment of various types of cancer. To carry out this study, different databases such as Web of Science, PubMed, MEDLINE and Google Scholar were employed. The findings of research studies chosen from more than 2000 viewed scientific publications from the last 15 years were compared.

摘要

癌症是发达国家人类死亡的主要原因之一。不幸的是,大多数当前的治疗方法都有一些副作用,如毒性和对健康细胞的损伤,以及耐药性和复发的风险。因此,癌症研究正在努力开发负面影响最小的治疗程序。基于纳米材料的系统的使用似乎就是其中之一。近年来,在生物医学应用中具有高潜力的纳米材料领域取得了巨大进展。碳纳米材料由于其独特的物理化学性质,在癌症治疗中的应用越来越受欢迎。它们的价值特别体现在它们能够将药物或小分子治疗剂递送到这些细胞中。通过表面功能化,它们可以特异性地靶向肿瘤组织,提高治疗潜力,并显著降低治疗的不良反应。因此,它们未来的潜在用途可能是作为药物输送的载体。本文综述了使用碳纳米材料治疗各种类型癌症的最新研究结果。为了进行这项研究,使用了不同的数据库,如 Web of Science、PubMed、MEDLINE 和 Google Scholar。从过去 15 年查看的 2000 多篇科学出版物中选择了研究结果进行比较。

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