Gavioli Camila Fátima Biancardi, Festa Neto Cyro, Tyring Stephen K, Silva Lana Luiza da Cruz, Oliveira Walmar Roncalli Pereira de
Department of Dermatology, Faculdade de Medicina, Universidade de São Paulo, São Paulo (SP), Brazil.
Department of Dermatology, University of Texas Health Science Center, Houston, United States of America.
An Bras Dermatol. 2018 Sep-Oct;93(5):716-718. doi: 10.1590/abd1806-4841.20186919.
The oncogenic role of high-risk HPV in anogenital, head and neck, and cervical cancer is well recognized, but not in skin cancer in the general population. Some authors have demonstrated their appearance mainly on the hands and feet, particularly in the area of the nail bed, which could be due to contamination with HPV types from anogenital regions. Here, we describe a case of genital HPV associated with SCC on the nose tip in an immunocompetent young man, which was confirmed by histopathological findings and in situ hybridization. The importance of this report is to highlight the potential role of HPV in the etiology of skin cancer in an immunocompetent individual.
高危型人乳头瘤病毒（HPV）在肛门生殖器、头颈部及宫颈癌中的致癌作用已得到充分认识，但在普通人群的皮肤癌中并非如此。一些作者已证明其主要出现在手和脚，特别是甲床区域，这可能是由于来自肛门生殖器区域的HPV类型污染所致。在此，我们描述了一例免疫功能正常的年轻男性鼻尖部鳞状细胞癌（SCC）伴生殖器HPV感染的病例，该病例经组织病理学检查和原位杂交得以确诊。本报告的重要性在于强调HPV在免疫功能正常个体皮肤癌病因学中的潜在作用。
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