Macias-Parra Mercedes, Rodriguez-Weber Miguel Angel, Moreno-Espinosa Sarbelio, Ceron-Trujillo Berenice, Ojeda-Diezbarroso Karla, DeAntonio Rodrigo, Cortes-Alcala Ricardo, Martinez Gustavo, Carreño-Manjarrez Roberto, Jiménez-Juárez Rodolfo Norberto
a Instituto Nacional de Pediatría , Ciudad de México , México.
b Departamento de Infectología , Hospital Infantil de México Federico Gómez , México City , México.
Hum Vaccin Immunother. 2018;14(12):2950-2954. doi: 10.1080/21645515.2018.1504541. Epub 2018 Oct 23.
Varicella-zoster virus causes varicella (chicken-pox), mainly in young children. Most cases are mild but serious complications can occur, resulting in significant morbidity and mortality. The objective of this study was to estimate the cost burden of varicella hospitalizations in two pediatric reference hospitals in Mexico. This retrospective observational study collected data on patients aged <18 years admitted to two third-level referral hospitals in Mexico. Cases were identified from hospital records using International Classification of Diseases Ninth Revision (ICD-9) codes 052 Chickenpox, or Tenth Revision (ICD-10) codes B01 Varicella (chickenpox). Data on demographic and clinical characteristics and resource use were collected from hospital records. Costs for hospital stay and interventions were obtained from the Mexican Institute for Social Security for 2015 and updated to 2017 costs. A total of 172 hospitalized varicella clinically-confirmed cases and 121 varicella- contacts (with epidemiological linkage to a clinically-confirmed case) were included. Thirty eight of the 172 cases (22.0%) experienced complications. There were no deaths. The median duration of hospitalization was 12 days for cases and 23 days for contacts. The median hospitalization cost was MXN 82,572 (USD 4,434) per case, and MXN 89,453 (USD 4,804) per contact. Although considered a mild disease, varicella was associated with a substantial cost burden in two Mexican third-level referral hospitals.
水痘带状疱疹病毒会引发水痘（即水痘），主要感染幼儿。大多数病例症状较轻，但也可能出现严重并发症，导致显著的发病率和死亡率。本研究的目的是估算墨西哥两家儿科参考医院中水痘住院治疗的成本负担。这项回顾性观察研究收集了墨西哥两家三级转诊医院收治的18岁以下患者的数据。通过使用国际疾病分类第九版（ICD - 9）编码052水痘，或第十版（ICD - 10）编码B01水痘（水痘），从医院记录中识别病例。从医院记录中收集了人口统计学和临床特征以及资源使用情况的数据。住院费用和干预措施费用取自墨西哥社会保障局2015年的数据，并更新为2017年的费用。总共纳入了172例临床确诊的水痘住院病例和121例水痘接触者（与临床确诊病例有流行病学关联）。172例病例中有38例（22.0%）出现并发症。无死亡病例。病例的住院中位时长为12天，接触者为23天。病例的住院中位费用为每例82,572墨西哥比索（4,434美元），接触者为每例89,453墨西哥比索（4,804美元）。尽管水痘被认为是一种轻症疾病，但在墨西哥两家三级转诊医院中，它仍带来了相当大的成本负担。
