Mohamed Sabah M A, Saber Taha, Taha Afaf A, Roshdy Hisham S, Shahien Noha E
J Egypt Soc Parasitol. 2017 Apr;47(1):137-143.
Schistosome antigens modulate host metabolic profiles in experimental animals. The effects of previous schistosome infection (PSI) and the development of metabolic syndrome remain unknown in humans. This study evaluated previous schistosome infection (PSI) related to metabolic syndrome (MS). A total of 547 participants aged >40 years from rural areas of Zagazig district were enrolled. Of them, 269 patients with. PSI and 305 normal served as controls. For all participants blood pressure, height, body weight and waist circumstance (WC) were measured. Blood samples were examined biochemically to determine triglyceride (TG), fasting blood glucose (FBG) and high-density lipoprotein cholesterol (HIDL-C). Associations between PSI and MS were evaluated using logistic regression. Patients with PSI had significantly lower levels of body mass index (BMI), WC, TG, insignificantly low levels of fasting -blood glucose (FBG) and significantly higher levels of high-density lipoprotein cholesterol (HDL-C) compared with controls. Prevalence of MS in PSI was significantly low than controls (32.7% vs. 42.3% respectively). PSI significantly associated with low prevalence of metabolic syndrome and its components, including central obesity, hypertension, hyperglycemia, hypertriglyceridemia and low HDL-C. Potential long-term effects of PSI may reduce metabolic syndrome risk.
血吸虫抗原可调节实验动物的宿主代谢谱。既往血吸虫感染（PSI）的影响以及代谢综合征在人类中的发展情况尚不清楚。本研究评估了与代谢综合征（MS）相关的既往血吸虫感染（PSI）。共纳入了扎加齐格区农村地区547名年龄>40岁的参与者。其中，269例有PSI的患者和305例正常人作为对照。对所有参与者测量血压、身高、体重和腰围（WC）。对血样进行生化检查以测定甘油三酯（TG）、空腹血糖（FBG）和高密度脂蛋白胆固醇（HDL-C）。使用逻辑回归评估PSI与MS之间的关联。与对照组相比，有PSI的患者体重指数（BMI）、WC、TG水平显著较低，空腹血糖（FBG）水平略低，高密度脂蛋白胆固醇（HDL-C）水平显著较高。PSI组中MS的患病率显著低于对照组（分别为32.7%和42.3%）。PSI与代谢综合征及其组成部分（包括中心性肥胖、高血压、高血糖、高甘油三酯血症和低HDL-C）的低患病率显著相关。PSI潜在的长期影响可能会降低代谢综合征风险。
