School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.
School of Nursing, University of Wollongong, Wollongong, NSW, Australia.
Front Endocrinol (Lausanne). 2021 Aug 12;12:728396. doi: 10.3389/fendo.2021.728396. eCollection 2021.
There are a growing number of publications that report an absence of inflammatory based disease among populations that are endemic to parasitic worms (helminths) demonstrating the ability of these parasites to potentially regulate human immune responses. The aim of this systematic review and meta-analysis was to determine the impact of helminth infection on metabolic outcomes in human populations.
Using PRISMA guidelines, six databases were searched for studies published up to August 2020. Random effects meta-analysis was performed to estimate pooled proportions with 95% confidence intervals using the Review Manager Software version 5.4.1.
Fourteen studies were included in the review. Fasting blood glucose was significantly lower in persons with infection (MD -0.22, 95% CI -0.40- -0.04, P=0.02), HbA1c levels were lower, although not significantly, and prevalence of the metabolic syndrome (P=0.001) and type 2 diabetes was lower (OR 1.03, 95% CI 0.34-3.09, P<0.0001). Infection was negatively associated with type 2 diabetes when comparing person with diabetes to the group without diabetes (OR 0.44, 95% CI 0.29-0.67, P=0.0001).
While infection with helminths was generally associated with improved metabolic function, there were notable differences in efficacy between parasite species. Based on the data assessed, live infection with resulted in the most significant positive changes to metabolic outcomes.
Website: PROSPERO Identified: CRD42021227619.
越来越多的出版物报告称，在寄生虫（蠕虫）流行的人群中，没有炎症性疾病，这表明这些寄生虫有可能调节人类的免疫反应。本系统评价和荟萃分析的目的是确定寄生虫感染对人类代谢结果的影响。
使用 PRISMA 指南，检索了截至 2020 年 8 月发表的研究。使用 Review Manager Software 版本 5.4.1 进行随机效应荟萃分析，使用 95%置信区间估计合并比例。
共有 14 项研究纳入本综述。感染者的空腹血糖明显降低（MD-0.22，95%CI-0.40- -0.04，P=0.02），HbA1c 水平较低，尽管不显著，代谢综合征（P=0.001）和 2 型糖尿病的患病率也较低（OR 1.03，95%CI 0.34-3.09，P<0.0001）。与无糖尿病组相比，糖尿病患者感染与 2 型糖尿病呈负相关（OR 0.44，95%CI 0.29-0.67，P=0.0001）。
虽然寄生虫感染通常与改善代谢功能有关，但不同寄生虫种类的疗效存在显著差异。根据评估的数据，活感染导致代谢结果的阳性变化最显著。
网址：PROSPERO 识别码：CRD42021227619。
