Liu T, Li H H, Sheng J J, Zhu S H
Department of Burn Surgery, Institute of Burns, the First Affiliated Hospital, Naval Medical University, Shanghai 200433, China.
Zhonghua Shao Shang Za Zhi. 2018 Aug 20;34(8):566-569. doi: 10.3760/cma.j.issn.1009-2587.2018.08.018.
Growth factors play critical roles in the process of wound healing. Application of growth factor locally is a good way of promoting wound healing, while it is easy to be hydrolyzed in wounds and its efficacy has dose- and time-dependent manner. Therefore, appropriate growth factor delivery system is needed to assist it to function in wounds. In addition to delivering growth factor directly to wounds, viral and non-viral vectors can be used for gene transfection of growth factor in wounds. The gene can be transformed to growth factor to promote wound healing by transcription and translation. This article reviews the advances in the research of delivery system of growth factor and the gene for promoting wound healing.
生长因子在伤口愈合过程中发挥着关键作用。局部应用生长因子是促进伤口愈合的一种好方法,然而它在伤口中容易被水解,并且其疗效具有剂量和时间依赖性。因此,需要合适的生长因子递送系统来辅助其在伤口中发挥作用。除了将生长因子直接递送至伤口外,病毒和非病毒载体可用于伤口中生长因子的基因转染。该基因可通过转录和翻译转化为生长因子以促进伤口愈合。本文综述了促进伤口愈合的生长因子及基因递送系统的研究进展。