Ranjan Sanjeev, Fontana Flavia, Ullah Hanif, Hirvonen Jouni, Santos Hélder A
Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland.
Laboratory of Radiochemistry, Department of Chemistry, University of Helsinki, FI-00014 Helsinki, Finland.
Ther Deliv. 2016 Oct;7(10):711-732. doi: 10.4155/tde-2016-0039.
Microparticles with controlled size and morphology are of significant interest in the field of drug delivery. Although advanced nanoparticles have been the object of a substantial number of reviews, fewer have focused on microparticles, especially for the delivery of drugs and growth factors to the wound site. Microparticles show distinct advantages, including ease of production and characterization, extended release properties, high drug loading and little concern about the toxicity as compared with the nanosized systems. This review presents an introduction to the pathophysiology of wound healing and provides an overview of some of the recent advances in microparticle-based drugs and growth factors delivery to wound sites.
具有可控尺寸和形态的微粒在药物递送领域备受关注。尽管先进的纳米颗粒已成为大量综述的对象，但关注微粒的较少，尤其是用于将药物和生长因子递送至伤口部位的情况。微粒具有明显的优势，包括易于生产和表征、缓释特性、高载药量以及与纳米系统相比对毒性的担忧较小。本综述介绍了伤口愈合的病理生理学，并概述了基于微粒的药物和生长因子向伤口部位递送的一些最新进展。
