Hajialilo M, Tayari P, Ghorbanihaghjo A, Khabbazi A, Malek Mahdavi A, Rashtchizadeh N
1 Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Lupus. 2018 Oct;27(12):1918-1925. doi: 10.1177/0961203318796285. Epub 2018 Aug 29.
Background Endothelial dysfunction plays an important role in pathogenesis of systemic lupus erythematosus (SLE). Considering the importance of serum soluble vascular cell adhesion molecule-1 as the most abundant of the circulating adhesion molecules increased as a result of endothelial dysfunction and the role of endothelin-1 in pathophysiology of SLE, this study aimed to evaluate serum soluble vascular cell adhesion molecule-1 and endothelin-1 levels in SLE patients compared to healthy subjects. Methods In this cross-sectional study, 60 SLE patients according to the Systemic Lupus International Collaborating Clinics classification criteria for SLE and 40 age and sex-matched healthy controls were included. In patients, clinical examination was performed and SLE disease activity index was assessed. Serum endothelin-1 and soluble vascular cell adhesion molecule-1 levels were measured using ELISA kits. Results The mean ± standard deviation age of patients and controls was 31.91 ± 7.66 and 33.20 ± 10.08 years, respectively. Compared to healthy controls, serum soluble vascular cell adhesion molecule-1 (1023.8 ± 352.96 vs. 866.06 ± 109.91) and endothelin-1 (77.83 ± 16.27 vs. 54.45 ± 12.01) was significantly higher in SLE patients ( P = 0.003 and P < 0.001, respectively). The most common organs involved in patients were skin, joint and kidney. There were no significant differences in serum soluble vascular cell adhesion molecule-1 and endothelin-1 levels according to organ involvement, activity of disease and the conventional serum markers of disease activity ( P > 0.05). There was no significant correlation between disease activity, organ involvement and negative or positivity of autoantibodies as well as serum complement with endothelin-1 and vascular cell adhesion molecule-1 levels ( P > 0.05). Conclusions Although our study revealed higher serum soluble vascular cell adhesion molecule-1 and endothelin-1 levels in SLE patients compared to healthy controls, there were no significant correlations between their serum levels with organ involvement and disease activity.
背景 内皮功能障碍在系统性红斑狼疮（SLE）的发病机制中起重要作用。鉴于血清可溶性血管细胞黏附分子-1作为因内皮功能障碍而升高的循环黏附分子中含量最丰富者的重要性以及内皮素-1在SLE病理生理学中的作用，本研究旨在评估SLE患者与健康受试者相比血清可溶性血管细胞黏附分子-1和内皮素-1水平。方法 在这项横断面研究中，纳入了60例根据系统性红斑狼疮国际协作临床分类标准确诊的SLE患者以及40例年龄和性别匹配的健康对照。对患者进行临床检查并评估SLE疾病活动指数。使用ELISA试剂盒测定血清内皮素-1和可溶性血管细胞黏附分子-1水平。结果 患者和对照的平均年龄±标准差分别为31.91±7.66岁和33.20±10.08岁。与健康对照相比，SLE患者血清可溶性血管细胞黏附分子-1（1023.8±352.96对866.06±109.91）和内皮素-1（77.83±16.27对54.45±12.01）显著更高（P分别为0.003和P<0.001）。患者中最常受累的器官是皮肤、关节和肾脏。根据器官受累情况、疾病活动度以及疾病活动的传统血清标志物，血清可溶性血管细胞黏附分子-1和内皮素-1水平无显著差异（P>0.05）。疾病活动度、器官受累情况以及自身抗体的阴性或阳性以及血清补体与内皮素-1和血管细胞黏附分子-1水平之间无显著相关性（P>0.05）。结论 尽管我们的研究显示SLE患者血清可溶性血管细胞黏附分子-1和内皮素-1水平高于健康对照，但其血清水平与器官受累情况和疾病活动度之间无显著相关性。
