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原位肝移植术后黏膜皮肤结核 1 例：诊断极具挑战性

A case report of mucocutaneous tuberculosis after orthotopic liver transplantation: a challenging diagnosis.

机构信息

Infectious Diseases and Tropical Medicine Department, Ospedale Policlinico San Martino IST, University of Genoa, Genoa, Italy.

Infectious Diseases Unit, Ente Ospedaliero Ospedali Galliera, Mura delle Cappuccine, 14, 16128, Genoa, Italy.

出版信息

BMC Infect Dis. 2018 Aug 29;18(1):431. doi: 10.1186/s12879-018-3347-7.

DOI:10.1186/s12879-018-3347-7
PMID:30157783
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6114782/
Abstract

BACKGROUND

Mycobacterium tuberculosis is responsible for high morbidity and mortality in immune-compromised hosts.

CASE PRESENTATION

We present a rare case of cutaneous tuberculosis after orthotopic liver transplantation without involvement of any other organs.

CONCLUSION

TB risk-factors assessment, careful LTBI screening and treatment according to national guidelines, as well as a reduction in missed opportunity for prevention are necessary to avoid MTB related disease in fragile patients.

摘要

背景

分枝杆菌属结核分枝杆菌是导致免疫功能低下宿主发病率和死亡率高的原因。

病例介绍

我们报告了一例肝移植后皮肤结核的罕见病例，无其他器官受累。

结论

评估结核病风险因素，根据国家指南进行仔细的 LTBI 筛查和治疗，以及减少预防机会的错失，对于避免脆弱患者发生 MTB 相关疾病是必要的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c66/6114782/8635a12efc58/12879_2018_3347_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c66/6114782/8635a12efc58/12879_2018_3347_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c66/6114782/8635a12efc58/12879_2018_3347_Fig1_HTML.jpg

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Treatment of Latent Tuberculosis Infection: An Updated Network Meta-analysis.潜伏性结核感染的治疗：一项更新的网络荟萃分析。
Ann Intern Med. 2017 Aug 15;167(4):248-255. doi: 10.7326/M17-0609. Epub 2017 Aug 1.
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Isoniazid Prophylaxis for Latent Tuberculosis Infections in Liver Transplant Recipients in a Tuberculosis-Endemic Area.
结核病流行地区肝移植受者潜伏性结核感染的异烟肼预防治疗
Ann Transplant. 2017 Jun 5;22:338-345. doi: 10.12659/AOT.902989.
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Posttransplant Tuberculosis.移植后结核病
Exp Clin Transplant. 2017 Feb;15(Suppl 1):10-15. doi: 10.6002/ect.mesot2016.L32.
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Eur Respir J. 2017 Feb 2;49(2). doi: 10.1183/13993003.02242-2016. Print 2017 Feb.
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