COSMIC-3D 为药物发现提供癌症遗传学的结构视角。
COSMIC-3D provides structural perspectives on cancer genetics for drug discovery.
机构信息
COSMIC, Wellcome Sanger Institute, Cambridge, UK.
Astex Pharmaceuticals, Cambridge, UK.
出版信息
Nat Genet. 2018 Sep;50(9):1200-1202. doi: 10.1038/s41588-018-0214-9.
Abstract
COSMIC-3D is a comprehensive integration of cancer mutations with protein structure across the human genome and structural proteome, seeking to support the identification and characterisation of protein targets for novel drug design in precision oncology. As an interactive system to explore cancer mutations in three-dimensions, COSMIC-3D is designed to enable a greater understanding of the functional impact of mutations, generate new hypotheses on which mutations are cancer drivers, and provide new opportunities for addressing these mutations pharmaceutically. This combination of genetics, structural proteomics, and drug development, can be best described as “mutation-guided drug design”.
摘要
COSMIC-3D 全面整合了人类基因组和结构蛋白质组中的癌症突变与蛋白质结构，旨在支持识别和描述新型精准肿瘤学药物设计的蛋白质靶标。作为一个用于在三维空间中探索癌症突变的交互式系统，COSMIC-3D 的设计目的是帮助人们更好地理解突变的功能影响，提出关于哪些突变是致癌驱动因素的新假设，并为通过药物解决这些突变提供新机会。这种遗传学、结构蛋白质组学和药物开发的结合，可以最好地描述为“基于突变的药物设计”。
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