Algenstaedt Petra, Stumpenhagen Alexandra, Westendorf Johannes
Department for Endocrinology and Diabetology, University Clinic Hamburg-Eppendorf, Martinistraße 52, D-20246 Hamburg, Germany.
Institute of Experimental Pharmacology and Toxicology, University Clinic Hamburg-Eppendorf, Martinistraße 52, D-20246 Hamburg, Germany.
Evid Based Complement Alternat Med. 2018 Aug 6;2018:3565427. doi: 10.1155/2018/3565427. eCollection 2018.
The effect of the daily consumption of (Noni) fruit juice on the physiological status of patients with diabetes type 2 (DT2) was tested over a period of two months.
(Noni) fruit juice (NFJ), 2 ml per kg bw per day, was consumed by twenty patients with DT2 after they underwent a standard treatment regimen including carbohydrate reduced diet and treatment with an antidiabetic drug and/or insulin. NFJ consumption started only after no further improvement was achieved. The intake of NFJ was terminated after eight weeks. The fasting blood sugar level was monitored every morning during the entire treatment period. Blood samples were taken before, at, and four and eight weeks after the start of NFJ intake. The analysis of the blood samples included the concentration of blood glucose, HbA1c, C-peptide, hs-CRP, triglycerides, total cholesterol, LDL, and HDL.
The consumption of NFJ by 20 patients with DT2 resulted in a significant mean decrease of the morning blood sugar level monitored over a period of eight weeks. While NFJ reduced the blood glucose level in several but not all hyperglycemic patients, it did not cause hypoglycemia in normoglycemic patients. NFJ consumption also reduced the mean HbA1c value significantly (p= 0.033). Significant decreases (p= 0.01) were also achieved for high sensitive CRP values in patients starting with high levels (>2 mg/L), whereas no change was observed in patients with normal values (< 2 mg/L). The level of C-peptide showed a significant mean increase after four weeks of NFJ consumption in those patients who started with low levels (<3 g/l, p=0.004, N=11) but not in patients with higher levels (> 3 g/L).
The daily consumption of NFJ has the potential to regulate elevated blood sugar levels and some other pathological parameters in patients with DT2. NFJ therefore serves as a suitable additive to the diet of diabetic patients.
在两个月的时间里测试了每日饮用诺丽果汁对2型糖尿病（DT2）患者生理状态的影响。
20名DT2患者在接受包括碳水化合物减量饮食以及使用抗糖尿病药物和/或胰岛素治疗的标准治疗方案后，每日每千克体重饮用2毫升诺丽果汁（NFJ）。仅在病情没有进一步改善后才开始饮用NFJ。八周后停止摄入NFJ。在整个治疗期间每天早晨监测空腹血糖水平。在开始摄入NFJ之前、开始时、开始后四周和八周采集血样。血样分析包括血糖、糖化血红蛋白（HbA1c）、C肽、超敏C反应蛋白（hs-CRP）、甘油三酯、总胆固醇、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）的浓度。
20名DT2患者饮用NFJ导致在八周时间里监测到的早晨血糖水平平均显著下降。虽然NFJ降低了部分但并非所有高血糖患者的血糖水平，但未在血糖正常的患者中引起低血糖。饮用NFJ还显著降低了平均糖化血红蛋白值（p = 0.033）。起始水平较高（>2毫克/升）的患者，其高敏C反应蛋白值也显著下降（p = 0.01），而起始值正常（<2毫克/升）的患者未观察到变化。在起始水平较低（<3微克/升，p = 0.004，N = 11）的患者中，饮用NFJ四周后C肽水平平均显著升高，而起始水平较高（>3微克/升）的患者则未出现这种情况。
每日饮用NFJ有可能调节DT2患者升高的血糖水平和其他一些病理参数。因此，NFJ可作为糖尿病患者饮食中的合适添加剂。
