Shoeb Ahsan, Alwar M C, Shenoy Preethi J, Gokul P
Post Graduate Student, Department of Pharmacology, Kasturba Medical College , Mangalore, Manipal University, Mangalore, Karnataka, India .
Professor, Department of Pharmacology, Kasturba Medical College , Mangalore, Manipal University, Mangalore, Karnataka, India .
J Clin Diagn Res. 2016 Apr;10(4):FF06-10. doi: 10.7860/JCDR/2016/17900.7650. Epub 2016 Apr 1.
The medicinal value of Morinda citrifolia L. (commonly known as Noni) has been explored in ancient folk remedies with a wide range of therapeutic utility, including antibacterial, antiviral, antifungal, antitumour, analgesic, hypotensive, anti-inflammatory and immune enhancing effects.
The present study was designed to evaluate the effects of Noni fruit juice on serum lipid profile in high fat diet induced murine model of dyslipidemia.
Hyperlipidemia was induced by feeding a cholesterol rich high fat diet for 45 days in wistar albino rats of either sex (n=8). Noni fruit juice administered at 50mg/kg/day and 100mg/kg/day, per oral, was compared with the standard drug Atorvastatin (10mg/kg/day, oral) fed for the latter 30 days. The blood samples were then sent for complete blood lipid profile, after 30 days of treatment. The data presented as mean ± SEM was analyzed using one-way ANOVA followed by Tukey's post-hoc test. The p <0.05 was considered as statistically significant.
The Noni fruit juice treated group showed a significant decrease in the total cholesterol, triglycerides and very low density lipoprotein - Cholesterol at both the doses when compared to the disease control (p<0.05). However, the decrease in the TC (102.75±9.79 mg/dL) and LDL-C (47.87±7.47 mg/dL) levels observed with the noni fruit juice at the 50mg/kg dose employed, failed to show a statistical significance when compared to atorvastatin.
The present study provides evidence for the hypolipidemic activity of Noni fruit juice in high fat diet induced hyperlipidemia in rats.
海巴戟天（俗称诺丽果）的药用价值在古代民间疗法中就已得到探索，具有广泛的治疗效用，包括抗菌、抗病毒、抗真菌、抗肿瘤、镇痛、降血压、抗炎和增强免疫等作用。
本研究旨在评估诺丽果汁对高脂饮食诱导的小鼠血脂异常模型血清脂质谱的影响。
选用雌雄皆有的Wistar白化大鼠（n = 8），通过喂食富含胆固醇的高脂饮食45天诱导高脂血症。将诺丽果汁以50mg/kg/天和100mg/kg/天的剂量口服给药，并与标准药物阿托伐他汀（10mg/kg/天，口服）在治疗的后30天进行比较。治疗30天后，采集血样进行全血脂谱检测。以均值±标准误表示的数据采用单因素方差分析，随后进行Tukey事后检验。p < 0.05被认为具有统计学意义。
与疾病对照组相比，诺丽果汁治疗组在两个剂量下的总胆固醇、甘油三酯和极低密度脂蛋白胆固醇均显著降低（p < 0.05）。然而，在50mg/kg剂量下，诺丽果汁使总胆固醇（102.75±9.79mg/dL）和低密度脂蛋白胆固醇（47.87±7.47mg/dL）水平降低，但与阿托伐他汀相比，未显示出统计学意义。
本研究为诺丽果汁对高脂饮食诱导的大鼠高脂血症具有降血脂活性提供了证据。
