Jambocus Najla Gooda Sahib, Ismail Amin, Khatib Alfi, Mahomoodally Fawzi, Saari Nazamid, Mumtaz Muhammad Waseem, Hamid Azizah Abdul
Faculty of Food Science and Technology, Universiti Putra Malaysia, Serdang, Malaysia.
Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.
Food Nutr Res. 2017 Jul 27;61(1):1338919. doi: 10.1080/16546628.2017.1338919. eCollection 2017.
: L. is widely used as a folk medicinal food plant to manage a panoply of diseases, though no concrete reports on its potential anti-obesity activity. This study aimed to evaluate the potential of leaf extracts (MLE60) in the prevention of weight gain and establish its phytochemical profile. : Male Sprague-Dawley rats were divided into groups based on a normal diet (ND) or high fat diet (HFD), with or without MLE60 supplementation (150 and 350 mg/kg body weight) and assessed for any reduction in weight gain. Plasma leptin, insulin, adiponectin, and ghrelin of all groups were determined. H NMR and LCMS methods were employed for phytochemical profiling of MLE60. : The supplementation of MLE60 did not affect food intake indicating that appetite suppression might not be the main anti-obesity mechanism involved. In the treated groups, MLE60 prevented weight gain, most likely through an inhibition of pancreatic and lipoprotein activity with a positive influence on the lipid profiles and a reduction in LDL levels . MLE60 also attenuated visceral fat deposition in treated subjects with improvement in the plasma levels of obesity-linked factors . Spectral analysis showed the presence of several bioactive compounds with rutin being more predominant. : MLE60 shows promise as an anti-obesity agents and warrants further research.
L.作为一种民间药用食用植物被广泛用于治疗多种疾病，不过关于其潜在抗肥胖活性尚无具体报道。本研究旨在评估叶提取物（MLE60）预防体重增加的潜力并确定其植物化学特征。将雄性斯普拉格 - 道利大鼠根据正常饮食（ND）或高脂饮食（HFD）分组，有或没有补充MLE60（150和350毫克/千克体重），并评估体重增加的减少情况。测定所有组的血浆瘦素、胰岛素、脂联素和胃泌素。采用核磁共振氢谱（H NMR）和液相色谱 - 质谱联用（LCMS）方法对MLE60进行植物化学分析。补充MLE60不影响食物摄入量，这表明食欲抑制可能不是其主要的抗肥胖机制。在治疗组中，MLE60预防了体重增加，最有可能是通过抑制胰腺和脂蛋白活性，对血脂谱产生积极影响并降低低密度脂蛋白水平。MLE60还减少了治疗对象的内脏脂肪沉积，改善了与肥胖相关因子的血浆水平。光谱分析表明存在几种生物活性化合物，其中芦丁更为主要。MLE60显示出作为抗肥胖剂的潜力，值得进一步研究。
