Rimkus K, Dhom G
J Cancer Res Clin Oncol. 1986;111(3):248-56. doi: 10.1007/BF00389241.
The present study is based on the data of 321 cases of primary liver cancer (PLC); 225 hepatocellular carcinomas (HCC), 54 cholangiocellular carcinomas (CCC) and 35 unclassified carcinomas autopsied between 1963 and 1982 or reported to the Saarland Cancer Registry between 1967 and 1981. The age standardized incidence rate for the Saarland was determined as 1.1. We noticed an increase in incidence for both HCC and CCC. The HCC rise was based on a significant (p less than 0.05) increase for women. The incidence maximum in the successive birth cohorts is shifting into younger age groups. The highest rates were observed in men and women born between 1900 and 1909. The regional distribution of PLC in the Saarland shows an accumulation in the urban areas. The mean survival time from diagnosis to death was 3.1 months. Prognosis was only influenced by the grade of differentiation. 88.3% of the HCC, but only 28.6% of CCC occurred in cirrhotic livers. Orcein staining of 55 liver specimens showed evidence of previous HBV infection in 12 out of 38 cases of HCC (31.6%) and no evidence of HBVB in the 17 cases of CCC studied.
本研究基于1963年至1982年间尸检的321例原发性肝癌（PLC）病例数据；其中225例为肝细胞癌（HCC），54例为胆管细胞癌（CCC），35例为未分类癌，或1967年至1981年间向萨尔州癌症登记处报告的病例。萨尔州的年龄标准化发病率确定为1.1。我们注意到HCC和CCC的发病率均有所上升。HCC的上升主要是由于女性发病率显著（p<0.05）增加。连续出生队列中的发病率峰值正转向更年轻的年龄组。在1900年至1909年间出生的男性和女性中观察到最高发病率。萨尔州PLC的区域分布显示在城市地区有聚集现象。从诊断到死亡的平均生存时间为3.1个月。预后仅受分化程度影响。88.3%的HCC发生在肝硬化肝脏中，但CCC只有28.6%发生在肝硬化肝脏中。对55份肝脏标本进行orcein染色显示，在38例HCC病例中有12例（31.6%）有既往HBV感染证据，而在研究的17例CCC病例中没有HBVB感染证据。
