Mathew Rishi Philip, Venkatesh Sudhakar Kundapur
Department of Radiology, Mayo Clinic, Mayo Clinic College of Medicine, 200, First Street SW, Rochester, MN, 55905, USA.
Curr Gastroenterol Rep. 2018 Aug 29;20(10):45. doi: 10.1007/s11894-018-0652-7.
The purpose of this review is to discuss the current imaging techniques for non-invasive assessment of liver fibrosis (LF).
Elastography-based techniques are the most widely used imaging methods for the evaluation of LF. Currently, MR elastography (MRE) is the most accurate non-invasive method for detection and staging of LF. Ultrasound-based vibration-controlled transient elastography (VCTE) is the most widely used as it can be easily performed at the point of care but has technical limitations especially in the obese. Innovations and technical improvements continue to evolve in elastography for improving accuracy and avoiding misinterpretation from confounding factors. Other imaging methods including diffusion-weighted imaging (DWI), hepatocellular contrast-enhanced (HCE) MRI, T1 relaxometry, T1ρ imaging, textural analysis, liver surface nodularity, susceptibility-weighted imaging, and perfusion imaging are promising but need further evaluation and clinical validation. MRE is the most accurate imaging technique for assessment of LF.
本综述旨在探讨目前用于非侵入性评估肝纤维化（LF）的成像技术。
基于弹性成像的技术是评估LF最广泛使用的成像方法。目前，磁共振弹性成像（MRE）是检测和分期LF最准确的非侵入性方法。基于超声的振动控制瞬时弹性成像（VCTE）应用最为广泛，因为它可以在床边轻松进行，但存在技术局限性，尤其是在肥胖患者中。弹性成像领域不断有创新和技术改进，以提高准确性并避免混杂因素导致的误判。其他成像方法，包括扩散加权成像（DWI）、肝细胞特异性对比增强（HCE）MRI、T1弛豫测量、T1ρ成像、纹理分析、肝表面结节、磁敏感加权成像和灌注成像等虽前景良好，但仍需进一步评估和临床验证。MRE是评估LF最准确的成像技术。
