Chicz R M, Shi Z, Regnier F E
J Chromatogr. 1986 May 30;359:121-30. doi: 10.1016/0021-9673(86)80067-x.
The use of alternate macroporous (greater than 200 A) inorganic support materials in the preparation of pellicular anion-exchange packings was explored. Alumina, magnesia, titania, and a zirconia-coated silica were chosen for comparison with silica. The stationary phase attached to the support surfaces was an adsorbed polyethyleneimine, crosslinked with 1,4-butanediol diglycidyl ether. Packing materials were characterized by static elemental analyses, chromatographic retention, static loading capacity and pH stability. Titania, alumina, and zirconyl-clad silica packings were found to be substantially more stable under alkaline conditions than silica-based materials. The data show that the stationary phase was successfully bonded in all cases and functioned in anion-exchange chromatography. When the surface area and pore diameter of these alternate materials is equivalent to silica, there is little difference in chromatographic properties.
探索了在制备薄壳型阴离子交换填料中使用交替的大孔（大于200埃）无机载体材料。选择氧化铝、氧化镁、二氧化钛和一种氧化锆涂覆的硅胶与硅胶进行比较。附着在载体表面的固定相是一种用1,4 - 丁二醇二缩水甘油醚交联的吸附聚乙烯亚胺。通过静态元素分析、色谱保留、静态负载容量和pH稳定性对填充材料进行表征。发现二氧化钛、氧化铝和氧化锆包覆的硅胶填料在碱性条件下比硅基材料稳定得多。数据表明，在所有情况下固定相都成功键合并在阴离子交换色谱中起作用。当这些替代材料的表面积和孔径与硅胶相当时，色谱性能几乎没有差异。
