银屑病中ADAM 33基因V4 C/G rs2787094多态性
ADAM 33 gene V4 C/G rs2787094 polymorphism in psoriasis.
作者信息
Akcilar R, Namdar N D, Kocak F E, Bayat Z, Burhan H
出版信息
Bratisl Lek Listy. 2018;119(7):454-457. doi: 10.4149/BLL_2018_084.
AIMS
Psoriasis is a common chronic inflammatory disease. A disintegrin and metalloproteinase 33 (ADAM33) gene is the first novel susceptibility gene for asthma. The aim of this study was to investigate the relationship of ADAM 33 gene V4 C/G rs2787094 polymorphism with the risk of psoriasis in the Turkish population.
METHODS
ADAM33 gene polymorphism (V4 C/G rs2787094) was analyzed in 97 psoriasis patients and 50 healthy control subjects. This study was performed by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) analysis.
RESULTS
There was no significant difference in ADAM33 genotype and allele distributions between psoriasis and control groups (p > 0.05).
CONCLUSIONS
ADAM33 V4 C/G rs2787094 polymorphism was not associated with psoriasis risk in the Turkish population. Larger studies with different ethnicities are needed to determine the impact of ADAM33 polymorphism on the risk of developing psoriasis (Tab. 3, Fig. 1, Ref. 16).
目的
银屑病是一种常见的慢性炎症性疾病。解整合素金属蛋白酶33（ADAM33）基因是首个被发现的哮喘易感新基因。本研究旨在探讨土耳其人群中ADAM33基因V4 C/G rs2787094多态性与银屑病发病风险的关系。
方法
对97例银屑病患者和50例健康对照者进行ADAM33基因多态性（V4 C/G rs2787094）分析。本研究采用基于聚合酶链反应的限制性片段长度多态性（PCR-RFLP）分析方法。
结果
银屑病组与对照组之间ADAM33基因型和等位基因分布无显著差异（p>0.05）。
结论
在土耳其人群中，ADAM33 V4 C/G rs2787094多态性与银屑病发病风险无关。需要开展针对不同种族的更大规模研究，以确定ADAM33多态性对银屑病发病风险的影响（表3，图1，参考文献16）。
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