Katayama Y, Sugimoto S, Inamura K, Soeda T, Shimizu J, Suzuki S, Nagazumi A, Terashi A
Jpn Circ J. 1986 Mar;50(3):258-64. doi: 10.1253/jcj.50.258.
The Wistar rat, with a blood pressure range of 120-160 mmHg, and two strains of spontaneously hypertensive rats (SHR), stroke-prone (SHRSP, range 210-270 mmHg) and stroke-resistant (SHRSR, range 160-240 mmHg), were used to determine the degree of damage after ischemic insult induced by bilateral carotid artery ligation (BLCL). The survival rate and McGraw Stroke Index correlated well with the degree of hypertension. After BLCL, impairment of cerebral blood flow is abrupt and residual flow is near zero in rats with initial blood pressures greater than 200 mmHg. A markedly deteriorated aerobic metabolism, as measured by the concentrations of ATP, c-AMP and lactate, is seen to precipitate in rats with initial blood pressures greater than 180 mmHg and severe edema occurs if the pressure is more than 160 mmHg. The degree of hypertension that produces high vulnerability to stroke and severe damage to the brain after ischemic insult is indicated as beginning at about 180 mmHg.
血压范围为120 - 160 mmHg的Wistar大鼠，以及两种自发性高血压大鼠品系，即易发生中风的（SHRSP，血压范围210 - 270 mmHg）和抗中风的（SHRSR，血压范围160 - 240 mmHg），被用于确定双侧颈动脉结扎（BLCL）诱导的缺血性损伤后的损伤程度。存活率和麦格劳中风指数与高血压程度密切相关。BLCL后，初始血压大于200 mmHg的大鼠脑血流量突然受损且残余血流量接近零。通过ATP、环磷酸腺苷（c - AMP）和乳酸浓度测量发现，初始血压大于180 mmHg的大鼠有氧代谢明显恶化，如果血压超过160 mmHg则会出现严重水肿。缺血性损伤后对中风高度易感性和对大脑严重损伤的高血压程度表明约从180 mmHg开始。
