Suno M, Kakihana M, Shibota M, Nagaoka A
Stroke. 1981 Mar-Apr;12(2):246-50. doi: 10.1161/01.str.12.2.246.
Neurological symptoms and cerebral metabolism following bilateral carotid artery occlusion (BCAO) were observed in stroke-prone spontaneously hypertensive rats (SHRSP), stroke-resistant SHR (SHRSR), normal Wistar-Kyoto rats (WKY) and the F1 and F2 hybrids between SHRSP and SHRSR or WKY. Systolic blood pressure recorded before BCAO was found to rank in the following order: SHRSP greater than F1 (SHRSP X SHRSR) greater than SHRSR greater than F1 (SHRSP X WKY) greater than WKY. The effect of BCAO in these rats tended to be proportional to the blood pressure. F1 (SHRSP X WKY) was more sensitive to brain ischemia than SHRSR. In addition, though none of the SHRSR (average blood pressure 155 mm Hg) developed acute stroke symptoms, many animals of the F2 generation, in which the blood pressure was equal to or lower than that of SHRSR, developed stroke symptoms. Lactate and ATP changes in the F2 generations did not correlate with the blood pressure. The results suggest that genetic factors may play an important role in susceptibility to brain ischemia in the stroke-prone rats.
在易患中风的自发性高血压大鼠（SHRSP）、抗中风的SHR（SHRSR）、正常的Wistar-Kyoto大鼠（WKY）以及SHRSP与SHRSR或WKY之间的F1和F2杂种中，观察了双侧颈动脉闭塞（BCAO）后的神经症状和脑代谢。发现BCAO前记录的收缩压按以下顺序排列：SHRSP＞F1（SHRSP×SHRSR）＞SHRSR＞F1（SHRSP×WKY）＞WKY。这些大鼠中BCAO的作用倾向于与血压成正比。F1（SHRSP×WKY）比SHRSR对脑缺血更敏感。此外，尽管没有一只SHRSR（平均血压155mmHg）出现急性中风症状，但许多血压等于或低于SHRSR的F2代动物出现了中风症状。F2代中乳酸和ATP的变化与血压无关。结果表明，遗传因素可能在易患中风大鼠对脑缺血的易感性中起重要作用。
