State Key Laboratory Explosion Science and Technology, School of Life Science , Beijing Institute of Technology , Beijing 100081 , China.
College of Information Science and Engineering , Northeastern University , Shenyang , Liaoning 110819 , China.
Anal Chem. 2018 Oct 2;90(19):11671-11679. doi: 10.1021/acs.analchem.8b03332. Epub 2018 Sep 12.
Previously, a miniature mass spectrometer driven by a sinusoidal frequency scanning technique, named as Brick mass spectrometer, was developed in our lab ( Jiang et al. Anal. Chem. 2017 , 89 , 5578 ). The frequency scanning technique enabled miniaturized electronics and broader mass range, but it was also limited in reduced mass resolution and sensitivity due to a relatively low operating radio frequency (rf) voltage in comparison with the conventional voltage scanning technique. To improve performances of the Brick mass spectrometer, a quadrupole enhanced dipolar resonance ejection (QE-dipolar resonance ejection) method was proposed in this work. After optimization, mass resolution and sensitivity of the Brick mass spectrometer could be improved by no less than 2 times, and space charge effects within the ion trap could also be reduced. Furthermore, this QE-dipolar resonance ejection method is effective at elevated pressures, which would potentially allow us to further miniaturize the Brick mass spectrometer by operating it at higher pressures. This method is also applicable to any ion trap operated in either frequency scanning mode or voltage scanning mode and operated in either miniaturized instruments or benchtop instruments.
先前，我们实验室开发了一种由正弦频率扫描技术驱动的微型质谱仪，名为 Brick 质谱仪（Jiang 等人，分析化学，2017 年，89 卷，5578 页）。频率扫描技术使电子设备小型化并扩大了质量范围，但与传统的电压扫描技术相比，由于相对较低的工作射频（rf）电压，其质量分辨率和灵敏度也受到限制。为了提高 Brick 质谱仪的性能，本工作提出了四极增强偶极共振引出（QE-偶极共振引出）方法。经过优化，Brick 质谱仪的质量分辨率和灵敏度可提高至少 2 倍，并且可以减小离子阱内的空间电荷效应。此外，这种 QE-偶极共振引出方法在高压下有效，这可能允许我们通过在更高的压力下操作来进一步小型化 Brick 质谱仪。该方法也适用于任何以频率扫描模式或电压扫描模式运行的离子阱，并且适用于任何小型化仪器或台式仪器。
