Li Chang, Chu Shiying, Tan Siyuan, Yin Xinchi, Jiang You, Dai Xinhua, Gong Xiaoyun, Fang Xiang, Tian Di
College of Instrumentation & Electrical Engineering, Jilin University, Changchun, China.
Technology Innovation Center of Mass Spectrometry for State Market Regulation, Center for Advanced Measurement Science, National Institute of Metrology, Beijing, People's Republic of China.
Front Chem. 2021 Dec 21;9:813359. doi: 10.3389/fchem.2021.813359. eCollection 2021.
Mass spectrometry (MS) is one of the most widely used analytical techniques in many fields. Recent developments in chemical and biological researches have drawn much attention to the measurement of substances with low abundances in samples. Continuous efforts have been made consequently to further improve the sensitivity of MS. Modifications on the mass analyzers of mass spectrometers offer a direct, universal and practical way to obtain higher sensitivity. This review provides a comprehensive overview of the latest developments in mass analyzers for the improvement of mass spectrometers' sensitivity, including quadrupole, ion trap, time-of-flight (TOF) and Fourier transform ion cyclotron (FT-ICR), as well as different combinations of these mass analyzers. The advantages and limitations of different mass analyzers and their combinations are compared and discussed. This review provides guidance to the selection of suitable mass spectrometers in chemical and biological analytical applications. It is also beneficial to the development of novel mass spectrometers.
质谱分析法（MS）是众多领域中使用最为广泛的分析技术之一。化学和生物学研究的最新进展使人们高度关注样品中低丰度物质的测量。因此，人们不断努力进一步提高质谱的灵敏度。对质谱仪质量分析器进行改进是获得更高灵敏度的一种直接、通用且实用的方法。本综述全面概述了用于提高质谱仪灵敏度的质量分析器的最新进展，包括四极杆、离子阱、飞行时间（TOF）和傅里叶变换离子回旋共振（FT-ICR），以及这些质量分析器的不同组合。比较并讨论了不同质量分析器及其组合的优缺点。本综述为化学和生物分析应用中合适质谱仪的选择提供了指导。它对新型质谱仪的开发也有益处。
