Ran Xuhua, Chen Xiaohong, Ma Lili, Wen Xiaobo, Zhai Junjun, Wang Miaomiao, Tong Xiaodan, Hou Guangyu, Ni Hongbo
College of Animal Science & Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province, 163319, China.
College of Basic Medicine, Mudanjiang Medical College, Mudanjiang, Heilongjiang Province, 157011, China.
Acta Trop. 2019 Feb;190:296-303. doi: 10.1016/j.actatropica.2018.08.031. Epub 2018 Aug 27.
Bovine viral diarrhea virus (BVDV) infection causes significantly economic losses to cattle industry worldwide, also including China. The epidemiological prevalence of infection associated with BVDV in dairy cattle has not been systematically assessed in China. Therefore, we undertook this study to evaluate prevalent of BVDV infection. We conducted a systematic review and meta-analysis of data from papers on the BVDV incidence and prevalence in dairy cattle in China by searching China Science and Technology Journal Database, China National Knowledge Infrastructure (CNKI), Wan Fang Database and PubMed for publication from March 2003 to March 2018. The 41 studies reporting the prevalence of BVDV in cattle in China were selected upon our inclusion criterion. The pooled BVDV prevalence in dairy cattle in China was estimated to 53.0% (95% CI 40.2-65.7) based on the data obtained from the 27,530 cows tested using serological or virological assay in the qualified papers published during the periods (χ² = 51,861.0, I = 99.9%). The highest BVDV positive rate in dairy flocks reached 90.0% in Fujian province of China, followed by Shaanxi (88.9%) and Shandong (83.3%). The prevalence in the six administrative districts of China was validated to be highly variable (25.7%-72.2%) and reached 72.2% in dairy cattle flocks of Northern China. Besides, the BVDV-RNA positive rate was estimated 27.1% (95% CI 17.3-37.0) based on 6 studies, comparatively, the pooled BVDV seroprevalence based on 35 studies was about 57.0% (95% CI 44.4-69.5) in China. This systematic review and meta-analysis firstly established an estimated prevalence of BVDV in dairy herds in China, indicating that the BVDV infection is escalating, though there is a bias in the number of studies between 2003-2009 and 2010-2018 timescales. This study may help understand the status of BVDV infection in dairy herds in China. Further extensive and comprehensive investigation is recommended, and effective intervention measures for preventing and controlling BVDV spread in dairy herds should be deployed, especially herds that have been exposed to BVDV.
牛病毒性腹泻病毒（BVDV）感染给包括中国在内的全球养牛业造成了巨大经济损失。在中国，尚未对奶牛中与BVDV相关的感染流行病学流行情况进行系统评估。因此，我们开展了本研究以评估BVDV感染的流行情况。我们通过检索中国科技期刊数据库、中国知网（CNKI）、万方数据库和PubMed，对2003年3月至2018年3月发表的有关中国奶牛BVDV发病率和流行率的论文数据进行了系统综述和荟萃分析。根据纳入标准，我们选取了41项报告中国牛群中BVDV流行率的研究。根据在这些时间段发表的合格论文中使用血清学或病毒学检测方法检测的27530头奶牛的数据，估计中国奶牛中BVDV的合并流行率为53.0%（95%置信区间40.2 - 65.7）（χ² = 51861.0，I = 99.9%）。中国福建省奶牛群中BVDV阳性率最高，达到90.0%，其次是陕西（88.9%）和山东（83.3%）。中国六个行政区的流行率经证实差异很大（25.7% - 72.2%），中国北方奶牛群中的流行率达到72.2%。此外，根据6项研究估计BVDV - RNA阳性率为27.1%（95%置信区间17.3 - 37.0），相比之下中国基于35项研究的BVDV血清阳性率合并约为57.0%（95%置信区间44.4 - 69.5）。这项系统综述和荟萃分析首次确定了中国奶牛群中BVDV的估计流行率，表明BVDV感染正在升级，尽管在2003 - 2009年和2010 - 2018年时间尺度之间的研究数量存在偏差。本研究可能有助于了解中国奶牛群中BVDV感染状况。建议进一步进行广泛而全面的调查，并应采取有效的干预措施来预防和控制BVDV在奶牛群中的传播，特别是那些已接触过BVDV的牛群。
