人类免疫缺陷病毒/艾滋病研究的扩展影响。
The Extended Impact of Human Immunodeficiency Virus/AIDS Research.
机构信息
Office of the Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
出版信息
J Infect Dis. 2019 Jan 1;219(1):6-9. doi: 10.1093/infdis/jiy441.
Abstract
Human immunodeficiency virus (HIV) is one of the most extensively studied viruses in history, and numerous extraordinary scientific advances, including an in-depth understanding of viral biology, pathogenesis, and life-saving antiretroviral therapies, have resulted from investments in HIV/AIDS research. While the substantial investments in HIV/AIDS research are validated solely on these advances, the collateral broader scientific progress resulting from the support of HIV/AIDS research over the past 30 years is extraordinary as well. The positive impact has ranged from innovations in basic immunology and structural biology to treatments for immune-mediated diseases and cancer and has had an enormous effect on the research and public and global health communities well beyond the field of HIV/AIDS. This article highlights a few select examples of the unanticipated and substantial positive spin-offs of HIV/AIDS research on other scientific areas.
摘要
人类免疫缺陷病毒（HIV）是历史上研究最广泛的病毒之一，对 HIV/AIDS 的研究投入带来了许多非凡的科学进展，包括对病毒生物学、发病机制和救命的抗逆转录病毒疗法的深入了解。虽然对 HIV/AIDS 研究的大量投资仅基于这些进展得到了验证，但过去 30 年来支持 HIV/AIDS 研究所带来的更广泛的科学进展也是非凡的。其积极影响范围从基础免疫学和结构生物学的创新到免疫介导疾病和癌症的治疗，对研究界、公共卫生界和全球卫生界产生了巨大影响，其影响远远超出了 HIV/AIDS 领域。本文重点介绍了 HIV/AIDS 研究对其他科学领域产生的一些意想不到的重大积极影响的几个精选实例。
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