Kalin N H, Shelton S E, Thompson R M, Barksdale C M
Neuroendocrinology. 1986;43(3):348-51. doi: 10.1159/000124550.
In two separate experiments, cerebrospinal fluid (CSF) adrenocorticotropin immunoreactive (ACTH-IR) concentrations in the rhesus monkey followed a significant rostral-caudal gradient. In the first study, CSF was sampled from an indwelling catheter in awake animals. The mean ACTH-IR concentration in the cisternal region was 12.3 pg/ml, as compared to 8.56 pg/ml in the lumbar region. In the second study, CSF was sampled in a different group of monkeys by percutaneous puncture at the cisterna magna and at L5-L6. In this study, the mean ACTH-IR concentration in samples collected from the cistern was also greater than the concentration from L5-L6. In addition, a significant correlation within subjects was found between samples collected from the two sites (r = 0.86). These results demonstrate that the site of CSF sampling is a variable in determining CSF ACTH-IR concentrations and suggest that lumbar CSF ACTH-IR concentrations in humans may be interpreted as indexes of ACTH changes at higher levels in the central nervous system.
在两项独立实验中，恒河猴脑脊液（CSF）中促肾上腺皮质激素免疫反应性（ACTH-IR）浓度呈现出显著的头-尾梯度。在第一项研究中，从清醒动物的留置导管采集脑脊液。脑池区域的平均ACTH-IR浓度为12.3 pg/ml，而腰段区域为8.56 pg/ml。在第二项研究中，通过经皮穿刺枕大池和L5-L6在另一组猴子中采集脑脊液。在这项研究中，从脑池采集的样本中的平均ACTH-IR浓度也高于从L5-L6采集的浓度。此外，在两个部位采集的样本之间发现受试者内存在显著相关性（r = 0.86）。这些结果表明，脑脊液采样部位是决定脑脊液ACTH-IR浓度的一个变量，并提示人类腰段脑脊液ACTH-IR浓度可被解释为中枢神经系统较高水平ACTH变化的指标。
