• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Balance of tofacitinib efficacy and disease flare in the treatment of alopecia universalis: A case report and review of the literature.

作者信息

Chiang Audris, Ortenzio Francesca, Juhasz Margit L W, Yu Vicky, Mesinkovska Natasha Atanaskova

机构信息

Department of Dermatology, School of Medicine, University of California, Irvine, California.

College of Medicine, University of Cincinnati, Cincinnati, Ohio.

出版信息

JAAD Case Rep. 2018 Aug 17;4(7):733-736. doi: 10.1016/j.jdcr.2018.04.006. eCollection 2018 Aug.

DOI:10.1016/j.jdcr.2018.04.006
PMID:30167448
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6113654/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed6/6113654/2f353b21ab31/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed6/6113654/2accf5615805/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed6/6113654/8df0b6b7604d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed6/6113654/e102a9ce6f6d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed6/6113654/2f353b21ab31/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed6/6113654/2accf5615805/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed6/6113654/8df0b6b7604d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed6/6113654/e102a9ce6f6d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed6/6113654/2f353b21ab31/gr4.jpg

相似文献

1
Balance of tofacitinib efficacy and disease flare in the treatment of alopecia universalis: A case report and review of the literature.托法替布治疗普秃的疗效与疾病复发平衡：一例病例报告及文献综述
JAAD Case Rep. 2018 Aug 17;4(7):733-736. doi: 10.1016/j.jdcr.2018.04.006. eCollection 2018 Aug.
2
Tofacitinib in Pediatric Alopecia Areata Totalis and Alopecia Universalis: A Retrospective Analysis From India.他卡西醇治疗儿童全秃和普秃：来自印度的回顾性分析。
J Cutan Med Surg. 2024 Sep-Oct;28(5):497-502. doi: 10.1177/12034754241266128. Epub 2024 Jul 26.
3
A Real-World Study of Steroid-Free Monotherapy with Tofacitinib in Severe and Therapy-Recalcitrant Alopecia Areata, Alopecia Totalis, and Alopecia Universalis Cases: A Retrospective Analysis.托法替布无类固醇单药治疗重度及治疗抵抗性斑秃、全秃和普秃病例的真实世界研究：一项回顾性分析
Indian Dermatol Online J. 2023 Nov 7;15(1):49-54. doi: 10.4103/idoj.idoj_131_23. eCollection 2024 Jan-Feb.
4
Excellent response to tofacitinib treatment in a patient with alopecia universalis.一名泛发性斑秃患者对托法替布治疗反应良好。
Acta Dermatovenerol Alp Pannonica Adriat. 2017 Jun;26(2):47-49. doi: 10.15570/actaapa.2017.15.
5
Treatment of severe alopecia areata with baricitinib.用巴瑞替尼治疗重度斑秃
JAAD Case Rep. 2019 Oct 22;5(10):892-894. doi: 10.1016/j.jdcr.2019.07.005. eCollection 2019 Oct.
6
Tofacitinib for the treatment of severe alopecia areata and variants: A study of 90 patients.托法替尼治疗严重斑秃及其变异型：90 例患者研究。
J Am Acad Dermatol. 2017 Jan;76(1):22-28. doi: 10.1016/j.jaad.2016.09.007. Epub 2016 Nov 2.
7
Clinical response to oral tofacitinib in pediatric patients with alopecia areata.托法替布口服治疗儿童斑秃的临床反应。
JAAD Case Rep. 2022 Aug 23;31:83-88. doi: 10.1016/j.jdcr.2022.08.024. eCollection 2023 Jan.
8
Case Report: Successful Treatment of Alopecia Universalis With Tofacitinib and Increased Cytokine Levels: Normal Therapeutic Reaction or Danger Signal?病例报告：托法替尼治疗普秃成功及细胞因子水平升高：正常治疗反应还是危险信号？
Front Immunol. 2022 Jun 20;13:904156. doi: 10.3389/fimmu.2022.904156. eCollection 2022.
9
Experience with oral tofacitinib in severe alopecia areata with different clinical responses.不同临床反应的严重斑秃患者接受口服托法替布治疗的经验。
J Cosmet Dermatol. 2021 Sep;20(9):3026-3033. doi: 10.1111/jocd.13966. Epub 2021 Feb 7.
10
Tofacitinib (Selective Janus Kinase Inhibitor 1 and 3): A Promising Therapy for the Treatment of Alopecia Areata: A Case Report of Six Patients.托法替布（选择性 Janus 激酶 1 和 3 抑制剂）：一种治疗斑秃的有前景的疗法：6 例患者的病例报告
Int J Trichology. 2018 May-Jun;10(3):103-107. doi: 10.4103/ijt.ijt_21_18.

引用本文的文献

1
Efficacy of Oral Tofacitinib in Alopecia Areata, Alopecia Totalis, and Alopecia Universalis.口服托法替布治疗斑秃、全秃和普秃的疗效。
Cureus. 2025 Apr 18;17(4):e82536. doi: 10.7759/cureus.82536. eCollection 2025 Apr.
2
Gene Variants Identified in Mexican Patients with Alopecia Areata.在墨西哥斑秃患者中鉴定出的基因变异
Curr Issues Mol Biol. 2023 Apr 3;45(4):2965-2971. doi: 10.3390/cimb45040194.
3
Effectiveness of Oral Tofacitinib Dose Tapering in a Case of Alopecia Areata Universalis.托法替布口服剂量递减治疗全秃一例的疗效

本文引用的文献

1
Janus kinase inhibitors in dermatology: A systematic review.皮肤科的 Janus 激酶抑制剂：系统评价。
J Am Acad Dermatol. 2017 Apr;76(4):745-753.e19. doi: 10.1016/j.jaad.2016.12.004. Epub 2017 Feb 4.
2
Health-related quality of life (HRQoL) among patients with alopecia areata (AA): A systematic review.斑秃患者的健康相关生活质量（HRQoL）：系统评价。
J Am Acad Dermatol. 2016 Oct;75(4):806-812.e3. doi: 10.1016/j.jaad.2016.04.035. Epub 2016 Jul 16.
3
Transient Efficacy of Tofacitinib in Alopecia Areata Universalis.托法替布治疗全秃的短期疗效
Skin Appendage Disord. 2021 Jan;7(1):36-40. doi: 10.1159/000510673. Epub 2020 Sep 30.
4
Scoping Review on the Use of Drugs Targeting JAK/STAT Pathway in Atopic Dermatitis, Vitiligo, and Alopecia Areata.关于靶向JAK/STAT通路药物在特应性皮炎、白癜风和斑秃中应用的范围综述
Dermatol Ther (Heidelb). 2019 Dec;9(4):655-683. doi: 10.1007/s13555-019-00329-y. Epub 2019 Oct 13.
5
Oral Tofacitinib: Contemporary Appraisal of Its Role in Dermatology.口服托法替布：其在皮肤科作用的当代评估
Indian Dermatol Online J. 2019 Aug 28;10(5):503-518. doi: 10.4103/idoj.IDOJ_474_18. eCollection 2019 Sep-Oct.
Case Rep Dermatol. 2016 Apr 22;8(1):102-6. doi: 10.1159/000445182. eCollection 2016 Jan-Apr.
4
Pharmacologic inhibition of JAK-STAT signaling promotes hair growth.对JAK-STAT信号通路的药理抑制可促进头发生长。
Sci Adv. 2015 Oct 23;1(9):e1500973. doi: 10.1126/sciadv.1500973. eCollection 2015 Oct.
5
Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib.斑秃经 JAK1/2 抑制剂巴瑞替尼治疗后逆转。
EBioMedicine. 2015 Feb 26;2(4):351-5. doi: 10.1016/j.ebiom.2015.02.015. eCollection 2015 Apr.
6
Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.斑秃由细胞毒性 T 淋巴细胞驱动，并可被 JAK 抑制逆转。
Nat Med. 2014 Sep;20(9):1043-9. doi: 10.1038/nm.3645. Epub 2014 Aug 17.
7
Killing two birds with one stone: oral tofacitinib reverses alopecia universalis in a patient with plaque psoriasis.一石二鸟：口服托法替布使一名斑块状银屑病患者的全秃症得到逆转。
J Invest Dermatol. 2014 Dec;134(12):2988-2990. doi: 10.1038/jid.2014.260. Epub 2014 Jun 18.
8
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.斑秃的全基因组关联研究提示固有免疫和适应性免疫均参与其中。
Nature. 2010 Jul 1;466(7302):113-7. doi: 10.1038/nature09114.
9
Incidence of alopecia areata in Olmsted County, Minnesota, 1975 through 1989.1975年至1989年明尼苏达州奥尔姆斯特德县斑秃的发病率。
Mayo Clin Proc. 1995 Jul;70(7):628-33. doi: 10.4065/70.7.628.
10
Lifetime prevalence of psychiatric disorders in patients with alopecia areata.斑秃患者精神障碍的终生患病率。
Compr Psychiatry. 1991 May-Jun;32(3):245-51. doi: 10.1016/0010-440x(91)90045-e.