Department of Surgery, Seoul National University Bundang Hospital, 300 Gumi-dong Bundang-gu, Seongnam, Gyeonggi-do, 463-707, Republic of Korea.
Advanced Medical Device Research Division, Korea Electrotechnology Research Institute, Seoul, Republic of Korea.
Surg Endosc. 2019 Apr;33(4):1235-1243. doi: 10.1007/s00464-018-6401-z. Epub 2018 Aug 27.
The aim of this study was to evaluate the feasibility of indocyanine green (ICG) fluorescent method for sentinel lymph node detection in early gastric cancer.
Between December 2012 and December 2014, 28 cases of pilot examination were performed at Seoul National University Bundang Hospital. Advanced version of multispectral fluorescence organoscope was used to identify sentinel node by quantitative estimation of ICG fluorescent signal intensity. Sensitivity, specificity, false positive value were analyzed and compared with dual tracer method.
A total of 443 lymph nodes in 28 cases were examined and 184 sentinel nodes (41.5%) were identified by dual tracer method. The sensitivity using near-infrared ICG method was 98.9%. The specificity was 76.0% and false positive rate was 25.4% compared with dual tracer method. The adequate threshold for sentinel node detection was considered as 10% of maximum signal intensity.
New near-infrared ICG fluorescent method could be a promising protocol for sentinel node navigation surgery in early gastric cancer.
本研究旨在评估吲哚菁绿（ICG）荧光法在早期胃癌前哨淋巴结检测中的可行性。
2012 年 12 月至 2014 年 12 月，在首尔国立大学盆唐医院进行了 28 例初步检查。使用定量评估 ICG 荧光信号强度的多光谱荧光内窥镜来识别前哨淋巴结。分析灵敏度、特异性、假阳性值，并与双示踪剂法进行比较。
共检查了 28 例 443 个淋巴结，通过双示踪剂法确定了 184 个前哨淋巴结（41.5%）。近红外 ICG 法的灵敏度为 98.9%。与双示踪剂法相比，特异性为 76.0%，假阳性率为 25.4%。前哨淋巴结检测的适当阈值被认为是最大信号强度的 10%。
新型近红外 ICG 荧光法可能是早期胃癌前哨淋巴结导航手术的一种有前途的方案。
