Gluckman J C
Rev Epidemiol Sante Publique. 1986;34(2):112-7.
LAV is the causative agent of AIDS. Its biological properties, assessed in vitro, fully account for the major immunological abnormalities which characterize the disease. LAV is a lentivirus which presents a selective tropism for T4+ lymphocytes, the very cells that are destroyed in AIDS. Its replication is associated with inhibition of lymphocyte proliferative capacity and with a cytopathic effect. In most instances, LAV infection is silent, for years at least, or it can result in various clinical syndromes among which AIDS is the most serious but the less frequent. Such a polymorphism can be explained by LAV biological properties and by the conjunction of numerous cofactors.
淋巴腺病相关病毒（LAV）是艾滋病的病原体。在体外评估的其生物学特性，充分解释了该疾病的主要免疫异常特征。LAV是一种慢病毒，对T4 +淋巴细胞具有选择性嗜性，而T4 +淋巴细胞正是在艾滋病中被破坏的细胞。其复制与淋巴细胞增殖能力的抑制以及细胞病变效应相关。在大多数情况下，LAV感染至少数年是无症状的，或者它可导致各种临床综合征，其中艾滋病是最严重但最不常见的。这种多态性可以通过LAV的生物学特性以及众多辅助因素的共同作用来解释。
