Kachru D N, Tandon S K
Res Commun Chem Pathol Pharmacol. 1986 Jun;52(3):399-402.
The effect of pre-treatment with sodium 2,3-dimercaptopropane 1-sulfonate (DMPS), sodium diethyldithiocarbamate (DDC) and calcium trisodium diethylenetriaminepentaacetate (DTPA) on the fate of injected mercuric chloride in rats was investigated. DMPS was the most effective chelator in reducing the uptake of Hg (203) in tissues and was the only chelator to enhance the urinary excretion of Hg (203). The results suggest affinity of Hg towards sulfur moiety and that the protective effects of pre-treatment are also shared by non-steroidal thiol chelators.
研究了用2,3-二巯基丙烷-1-磺酸钠（DMPS）、二乙基二硫代氨基甲酸钠（DDC）和三钠二乙三胺五乙酸钙（DTPA）预处理对大鼠注射氯化汞后汞的去向的影响。DMPS是降低组织中汞（203）摄取最有效的螯合剂，也是唯一能促进汞（203）尿排泄的螯合剂。结果表明汞对硫部分具有亲和力，并且非甾体硫醇螯合剂也具有预处理的保护作用。
