Aposhian M M, Maiorino R M, Xu Z, Aposhian H V
Department of Molecular and Cellular Biology, University of Arizona, Tuscon, AZ 85721, USA.
Toxicology. 1996 May 3;109(1):49-55. doi: 10.1016/0300-483x(96)03308-2.
Since there has been concern about whether any of the chelating agents used therapeutically might cause an initial redistribution of heavy metals to the brain and since the sodium salt of 2,3-dimercapto-1-propanesulfonic acid (Dimaval, DMPS) has been used to treat heavy metal intoxication in humans, the hypothesis that DMPS does not redistribute and increase lead or mercuric ions in the brains of rats was tested. Lead acetate at a concentration of 50 mg/l was made available in the drinking water of rats for 86 days. Other rats received intraperitoneal injections of 0.50 mg Hg/kg (as mercuric chloride) each day for 5 days a week for a total of 32 or 41 days. Animals were divided into groups and given, i.p., either 0.27 mmol DMPS/kg body weight or saline, each day for 1, 2, 3 or 4 days. Lead or mercury concentrations of the brain were determined after each group received DMPS for the different number of days. DMPS treatment did not result in any initial increase of lead or mercuric ions in the brain. The mercury content of the kidney decreased. The results of these experiments demonstrated that lead or mercuric ions were not redistributed to or increased in the brains of rats during the initial days of DMPS treatment.
由于人们一直关注治疗中使用的任何螯合剂是否可能导致重金属最初重新分布到大脑，并且由于2,3-二巯基-1-丙磺酸钠盐（二巯丙磺钠，DMPS）已被用于治疗人类重金属中毒，因此对DMPS不会在大鼠大脑中重新分布并增加铅或汞离子的假说进行了测试。将浓度为50 mg/l的醋酸铅提供给大鼠饮用水86天。其他大鼠每周5天每天腹腔注射0.50 mg Hg/kg（以氯化汞形式），共32或41天。将动物分成几组，每天腹腔注射0.27 mmol DMPS/kg体重或生理盐水，持续1、2、3或4天。在每组接受不同天数的DMPS治疗后，测定大脑中的铅或汞浓度。DMPS治疗并未导致大脑中铅或汞离子的任何初始增加。肾脏中的汞含量降低。这些实验结果表明，在DMPS治疗的最初几天，铅或汞离子不会重新分布到大鼠大脑中或在其中增加。
