Mayo S L, Ellis W R, Crutchley R J, Gray H B
Science. 1986 Aug 29;233(4767):948-52. doi: 10.1126/science.3016897.
Kinetic experiments have conclusively shown that electron transfer can take place over large distances (greater than 10 angstroms) through protein interiors. Current research focuses on the elucidation of the factors that determine the rates of long-range electron-transfer reactions in modified proteins and protein complexes. Factors receiving experimental and theoretical attention include the donor-acceptor distance, changes in geometry of the donor and acceptor upon electron transfer, and the thermodynamic driving force. Recent experimental work on heme proteins indicates that the electron-transfer rate falls off exponentially with donor-acceptor distance at long range. The rate is greatly enhanced in proteins in which the structural changes accompanying electron transfer are very small.
动力学实验已确凿表明，电子转移可通过蛋白质内部在远距离（大于10埃）发生。当前的研究集中于阐明决定修饰蛋白质和蛋白质复合物中长程电子转移反应速率的因素。受到实验和理论关注的因素包括供体 - 受体距离、电子转移时供体和受体几何结构的变化以及热力学驱动力。近期关于血红素蛋白的实验工作表明，在长程情况下，电子转移速率随供体 - 受体距离呈指数下降。在伴随电子转移的结构变化非常小的蛋白质中，该速率会大大提高。
